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Serial serum cholinesterase activities as a prognostic factor in organophosphate poisoned patients

Title
Serial serum cholinesterase activities as a prognostic factor in organophosphate poisoned patients
Authors
Yun H.W.Lee D.H.Lee J.H.Cheon Y.J.Choi Y.H.
Ewha Authors
전영진최윤희
SCOPUS Author ID
전영진scopus; 최윤희scopus
Issue Date
2012
Journal Title
Hong Kong Journal of Emergency Medicine
ISSN
1024-9079JCR Link
Citation
vol. 19, no. 2, pp. 92 - 97
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Objective: Organophosphate poisoning is a serious clinical entity and of considerable morbidity and mortality. Several factors have been identified to predict outcomes of organophosphate poisoning. This investigation aims to identify the relationship between the dynamics of serum cholinesterase (SChE) activity and mortality. Methods: In this retrospective study, medical records of all patients with acute organophosphate poisoning were reviewed from January 2001 to December 2009. Clinical features, SChE activity, Glasgow Coma Scale, laboratory findings, electrocardiogram finding, management and their outcomes were examined. Results: A total of 169 patients were included in this study. A total of 55 patients were enrolled. Deceased patients were 8 in number. Absence of an increase in SChE activity was related with mortality in organophosphate poisoned patients (p value=0.036; odds ratio, 5.445; 95% confidence interval, 1.121-26.551). Conclusions: The absence of an increase in SChE activity is associated with higher mortality in organophosphate poisoning. The SChE dynamic activity can provide a guide to physicians in the evaluation and management of organophosphate poisoned patients.
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의학전문대학원 > 의학과 > Journal papers
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