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Immune dysregulation in chronic stress: A quantitative and functional assessment of regulatory T cells

Title
Immune dysregulation in chronic stress: A quantitative and functional assessment of regulatory T cells
Authors
Kim H.-R.Moon S.Lee H.K.Kang J.L.Oh S.Seoh J.-Y.
Ewha Authors
서주영이지희오세관이현국김형란
SCOPUS Author ID
서주영scopus; 이지희scopus; 오세관scopus; 이현국scopus; 김형란scopus
Issue Date
2012
Journal Title
NeuroImmunoModulation
ISSN
1021-7401JCR Link
Citation
vol. 19, no. 3, pp. 187 - 194
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Objective: Chronic stress is closely related to immune dysfunction. Immune parameters have been analyzed in many ways in humans and animals under chronic stress. Recently, it has been proved that FoxP3+ regulatory T cells (Tregs) play a key role in immune regulation in vivo. However, it has not yet been elucidated how Tregs respond to chronic stress in vivo. Therefore, in the present study, we investigated the frequency of and functional changes in Tregs from mice under chronic stress. Methods: Spleen cells were separated from C57/BL6 mice that had been exposed to immobilization stress for 3 weeks. The frequencies of FoxP3+ and CD4+ CD25+ cells were analyzed by flow cytometry. CD4+CD25- cells (effector T cells, Teffs), CD4+CD25+ cells (Tregs) and CD4- cells (antigen-presenting cells, APCs) were separated for the functional assessment of the proliferative activity of Teffs, the suppressive activity of Tregs and the feeder activity of APCs. Results: The results showed that chronic immobilization stress significantly increased the frequencies of CD4+CD25+ and CD4+FoxP3+ cells. Chronic immobilization stress also enhanced the suppressive function of CD4+ CD25+ Tregs. On the other hand, the proliferative activity of Teffs and the feeder activity of APCs were decreased in the mice under chronic immobilization stress. Conclusion: Taken together, it is suggested that increased number and function of Tregs may actively contribute to the immune dysfunction in chronic immobilization stress, synergizing with the decreased function of Teffs and APCs. Copyright © 2012 S. Karger AG, Basel.
DOI
10.1159/000331586
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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