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Ectopic paragonimiasis from 400-year-old female mummy of Korea

Title
Ectopic paragonimiasis from 400-year-old female mummy of Korea
Authors
Shin D.H.Oh C.S.Lee S.J.Lee E.-J.Yim S.G.Kim M.J.Kim Y.-S.Lee S.D.Lee Y.S.Lee H.J.Seo M.
Ewha Authors
김이석
SCOPUS Author ID
김이석scopus
Issue Date
2012
Journal Title
Journal of Archaeological Science
ISSN
0305-4403JCR Link
Citation
vol. 39, no. 4, pp. 1103 - 1110
Indexed
SCIE; SSCI; AHCI; SCOPUS WOS scopus
Abstract
Of the parasite eggs discovered in ancient samples from Korean archaeological sites, Paragonimus spp. are of particular importance in that they are regarded as one of the most insidious trematode infection sources. Although their infection prevalence decreased rapidly in the early 20th century, archaeoparasitological studies on the species are still required, as historical knowledge of paragonimiasis remains far from comprehensive. Fortunately, we recently were given a chance to examine a medieval Korean mummy in a good state of preservation. Using morphological techniques, we discovered evidence of ectopic paragonimiasis in the sample from the 17th-century female. When the ITS 2 gene was extracted, amplified and sequenced from Paragonimus eggs, it showed 100% homology to the sequences of modern Paragonimus westermani reported from Korea and Japan, forming a cluster distinct from South Asian P.westermani. Our report is the first-ever analysis of ancient Paragonimus DNA from any archaeological field in the world. The ectopic paragonimiasis diagnosis made in this study, especially involving the liver sample, also is the first of its kind in archaeoparasitology. © 2011 Elsevier Ltd.
DOI
10.1016/j.jas.2011.12.011
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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