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VEGFA and VEGFR2 genetic polymorphisms and survival in patients with diffuse large b cell lymphoma

Title
VEGFA and VEGFR2 genetic polymorphisms and survival in patients with diffuse large b cell lymphoma
Authors
Kim M.K.Suh C.Chi H.S.Cho H.S.Bae Y.K.Lee K.H.Lee G.-W.Kim I.-S.Eom H.-S.Kong S.-Y.Bae S.H.Ryoo H.M.Shin I.-H.Mun Y.-C.Chung H.Hyun M.S.
Ewha Authors
정화순문영철
SCOPUS Author ID
정화순scopus; 문영철scopus
Issue Date
2012
Journal Title
Cancer Science
ISSN
1347-9032JCR Link
Citation
vol. 103, no. 3, pp. 497 - 503
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
We evaluated the impact of functional polymorphisms in the vascular endothelial growth factor A (VEGFA) and vascular endothelial growth factor 2 (VEGFR2) genes on the survival of patients with diffuse large B cell lymphoma (DLBCL). Five potentially functional polymorphisms in the VEGFA (rs699947, rs2010963 and rs3025039) and VEGFR2 (rs1870377 and rs2305948) genes were assessed in 494 DLBCL patients treated with rituximab plus CHOP chemotherapy. The associations of genotype and haplotype with overall survival (OS) and progression-free survival (PFS) were analyzed. Of the five polymorphisms, VEGFR2 rs1870377T>A was significantly associated with both OS and PFS; in the dominant model, patients with the AA + TA genotypes had significantly better OS (P = 0.002) and PFS (P = 0.004) than those with the TT genotype. The association between significantly better OS and the AA + TA genotypes was observed separately in patients with low (0-2; P = 0.035) and high (3-5; P = 0.043) International Prognostic Index scores. Multivariate analysis showed that, relative to the AA + TA genotypes, the TT genotype was an independent prognostic factor for poor OS (HR, 1.71; 95% CI, 1.21-2.43; P = 0.002) and PFS (HR, 1.57; 1.13-2.17; P = 0.004). Other independent significant predictors of survival in patients with DLBCL were International Prognostic Index score, age > 60 years, lactate dehydrogenase concentration >normal, extranodal disease >1 and presence of B symptoms. The VEGFR2 rs1870377 polymorphism might affect survival in patients with DLBCL, suggesting that angiogenesis might be related to poor survival in these patients. © 2011 Japanese Cancer Association.
DOI
10.1111/j.1349-7006.2011.02168.x
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의학전문대학원 > 의학과 > Journal papers
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