Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 정재철 | * |
dc.date.accessioned | 2016-08-28T12:08:59Z | - |
dc.date.available | 2016-08-28T12:08:59Z | - |
dc.date.issued | 2012 | * |
dc.identifier.issn | 1420-3049 | * |
dc.identifier.other | OAK-8507 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/222401 | - |
dc.description.abstract | The total synthesis and structure determination of cis- and trans-flocoumafen was described. The key synthetic steps involve Knoevenagel condensation with p-methoxybenzaldehyde, in situ decarboxylation and intramolecular ring cyclization to construct the tetralone skeleton. Stereospecific reduction of the O-alkylated ketone 13 afforded good yield of precusor alcohol 5. Final coupling of alcohol 5 with 4-hydroxycoumarin yielded flocoumafen (1). Separation and structure determination of cis- and trans-flocoumafen through 2D NMR analyses-assisted computer simulation techniques for the evaluation of anticoagulant activities are reported for the first time. This method is useful for generating the core tetralone skeleton of 4-hydroxycoumarin derivatives and provides a generalized access to various warfarin type anticoagulants. | * |
dc.language | English | * |
dc.title | Total synthesis of flocoumafen via knoevenagel condensation and intramolecular ring cyclization: General access to natural products | * |
dc.type | Article | * |
dc.relation.issue | 2 | * |
dc.relation.volume | 17 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 2091 | * |
dc.relation.lastpage | 2102 | * |
dc.relation.journaltitle | Molecules | * |
dc.identifier.doi | 10.3390/molecules17022091 | * |
dc.identifier.wosid | WOS:000300717200066 | * |
dc.identifier.scopusid | 2-s2.0-84863134868 | * |
dc.author.google | Jung J.-C. | * |
dc.author.google | Lim E. | * |
dc.author.google | Lee Y. | * |
dc.author.google | Min D. | * |
dc.author.google | Ricci J. | * |
dc.author.google | Park O.-S. | * |
dc.author.google | Jung M. | * |
dc.contributor.scopusid | 정재철(7402897187) | * |
dc.date.modifydate | 20240123112233 | * |