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dc.contributor.author황은숙*
dc.date.accessioned2016-08-28T12:08:58Z-
dc.date.available2016-08-28T12:08:58Z-
dc.date.issued2012*
dc.identifier.issn0022-1767*
dc.identifier.otherOAK-8489*
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/222383-
dc.description.abstractIL-10 is a multifunctional cytokine that plays a crucial role in immunity and tolerance. IL-10 is produced by diverse immune cell types, including B cells and subsets of T cells. Although Th1 produce IL-10, their expression levels are much lower than Th2 cells under conventional stimulation conditions. The potential role of E26 transformation-specific 1 (Ets-1) transcription factor as a negative regulator for Il10 gene expression in CD4 + T cells has been implicated previously. In this study, we investigated the underlying mechanism of Ets-1-mediated Il10 gene repression in Th1 cells. Compared with wild type Th1 cells, Ets-1 knockout Th1 cells expressed a significantly higher level of IL-10, which is comparable with that of wild type Th2 cells. Upregulation of IL-10 expression in Ets-1 knockout Th1 cells was accompanied by enhanced chromatin accessibility and increased recruitment of histone H3 acetylation at the Il10 regulatory regions. Reciprocally, Ets-1 deficiency significantly decreased histone deacetylase 1 (HDAC1) enrichment at the Il10 regulatory regions. Treatment with trichostatin A, an inhibitor of HDAC family, significantly increased Il10 gene expression by increasing histone H3 acetylation recruitment. We further demonstrated a physical interaction between Ets-1 and HDAC1. Coexpression of Ets-1 with HDAC1 synergistically repressed IL-10 transcription activity. In summary, our data suggest that an interaction of Ets-1 with HDAC1 represses the Il10 gene expression in Th1 cells. Copyright © 2012 by The American Association of Immunologists, Inc.*
dc.languageEnglish*
dc.titleInteraction of Ets-1 with HDAC1 represses IL-10 expression in Th1 cells*
dc.typeArticle*
dc.relation.issue5*
dc.relation.volume188*
dc.relation.indexSCI*
dc.relation.indexSCIE*
dc.relation.indexSCOPUS*
dc.relation.startpage2244*
dc.relation.lastpage2253*
dc.relation.journaltitleJournal of Immunology*
dc.identifier.doi10.4049/jimmunol.1101614*
dc.identifier.wosidWOS:000300610800025*
dc.identifier.scopusid2-s2.0-84863184174*
dc.author.googleLee C.-G.*
dc.author.googleKwon H.-K.*
dc.author.googleSahoo A.*
dc.author.googleHwang W.*
dc.author.googleSo J.-S.*
dc.author.googleHwang J.-S.*
dc.author.googleChae C.-S.*
dc.author.googleKim G.-C.*
dc.author.googleKim J.-E.*
dc.author.googleSo H.-S.*
dc.author.googleHwang E.S.*
dc.author.googleGrenningloh R.*
dc.author.googleHo I.-C.*
dc.author.googleIm S.-H.*
dc.contributor.scopusid황은숙(8688011100)*
dc.date.modifydate20240123102458*
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약학대학 > 약학과 > Journal papers
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