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IL-33 induces Th17-mediated airway inflammation via mast cells in ovalbumin-challenged mice
- Title
- IL-33 induces Th17-mediated airway inflammation via mast cells in ovalbumin-challenged mice
- Authors
- Cho K.-A.; Suh J.W.; Sohn J.H.; Park J.W.; Lee H.; Kang J.L.; Woo S.-Y.; Cho Y.J.
- Ewha Authors
- 이지희; 조영주; 우소연; 조경아
- SCOPUS Author ID
- 이지희; 조영주; 우소연; 조경아
- Issue Date
- 2012
- Journal Title
- American Journal of Physiology - Lung Cellular and Molecular Physiology
- ISSN
- 1040-0605
- Citation
- American Journal of Physiology - Lung Cellular and Molecular Physiology vol. 302, no. 4, pp. L429 - L440
- Indexed
- SCI; SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Allergic asthma is characterized by infiltration of eosinophils, elevated Th2 cytokine levels, airway hyperresponsiveness, and IgE. In addition to eosinophils, mast cells, and basophils, a variety of cytokines are also involved in the development of allergic asthma. The pivotal role of eosinophils in the progression of the disease has been a subject of controversy. To determine the role of eosinophils in the progression of airway inflammation, we sensitized and challenged BALB/c wild-type (WT) mice and eosinophil-deficient ΔdblGATA mice with ovalbumin (OVA) and analyzed different aspects of inflammation. We observed increased eosinophil levels and a Th2-dominant response in OVA-challenged WT mice. In contrast, eosinophil-deficient ΔdblGATA mice displayed an increased proportion of mast cells and a Th17-biased response following OVA inhalation. Notably, the levels of IL-33, an important cytokine responsible for Th2 immune deviation, were not different between WT and eosinophil-deficient mice. We also demonstrated that mast cells induced Th17-differentiation via IL-33/ST2 stimulation in vitro. These results indicate that eosinophils are not essential for the development of allergic asthma and that mast cells can skew the immune reaction predominantly toward Th17 responses via IL-33 stimulation. © 2012 the American Physiological Society.
- DOI
- 10.1152/ajplung.00252.2011
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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