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Peroxiredoxin functions as a peroxidase and a regulator and sensor of local peroxides

Title
Peroxiredoxin functions as a peroxidase and a regulator and sensor of local peroxides
Authors
Rhee S.G.Woo H.A.Kil I.S.Bae S.H.
Ewha Authors
이서구배수한길인섭우현애
SCOPUS Author ID
이서구scopusscopus; 우현애scopus
Issue Date
2012
Journal Title
Journal of Biological Chemistry
ISSN
0021-9258JCR Link
Citation
vol. 287, no. 7, pp. 4403 - 4410
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Peroxiredoxins (Prxs) contain an active site cysteine that is sensitive to oxidation by H 2O 2. Mammalian cells express six Prx isoforms that are localized to various cellular compartments. The oxidized active site cysteine of Prx can be reduced by a cellular thiol, thus enabling Prx to function as a locally constrained peroxidase. Regulation of Prx via phosphorylation in response to extracellular signals allows the local accumulation of H 2O 2 and thereby enables its messenger function. The fact that the oxidation state of the active site cysteine of Prx can be transferred to other proteins that are less intrinsically susceptible to H 2O 2 also allows Prx to function as an H 2O 2 sensor. © 2012 by The American Society for Biochemistry and Molecular Biology, Inc.
DOI
10.1074/jbc.R111.283432
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일반대학원 > 생명·약학부 > Journal papers
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