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Association of human adenovirus-36 in overweight Korean adults

Title
Association of human adenovirus-36 in overweight Korean adults
Authors
Na H.-N.Kim J.Lee H.S.Shim K.W.Kimm H.Jee S.H.Jo I.Nam J.-H.
Ewha Authors
이홍수심경원조인호
SCOPUS Author ID
이홍수scopus; 심경원scopus; 조인호scopus
Issue Date
2012
Journal Title
International Journal of Obesity
ISSN
0307-0565JCR Link
Citation
vol. 36, no. 2, pp. 281 - 285
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Background: Although human adenovirus-36 (Ad-36) has been reported to be associated with obesity in US adults and children, Korean children and the Italian population, the association has not been found in Dutch or Belgian populations or in US military subjects. Therefore, we examined whether Ad-36 infection is associated with obesity in Korean adults. Methods: A total of 540 age- and sex-matched individuals, who were normal weight, overweight or obese, were selected from participants in routine health examinations at the Ewha Womans University Medical Center. Overweight participants were defined as those with a body mass index (BMI) of 23≤BMI<25 kg m -2 and obese subjects were those with BMI≥25 kg m -2, according to the International Obesity Task Force definition. Ad-36 antibody was measured using a serum neutralization assay. Results: Although more overweight participants than normal or obese subjects tested positive for the Ad-36 antibody (40%, 32.8% and 30%, respectively), the differences were not significant. The participants who tested positive for Ad-36 antibody had lower levels of triglycerides (TG) in each of the three groups, higher total cholesterol (TC) in the obese group and higher high-density lipoprotein-cholesterol (HDL-C) in both the normal and obese groups. The odds ratio (OR) for Ad-36 antibody positivity was greater in overweight than in normal subjects (OR=2.03; 95% confidence interval (CI), 1.16-3.55) after adjusting for age, sex and waist circumference. However, this OR was non-significant in the obese group (OR=1.56; 95% CI, 0.67-3.67). Conclusion: Ad-36 seems to be strongly associated with overweight, but not obese, Korean adults. © 2012 Macmillan Publishers Limited All rights reserved.
DOI
10.1038/ijo.2011.102
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의학전문대학원 > 의학과 > Journal papers
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