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Brazilin inhibits UVB-induced MMP-1/3 expressions and secretions by suppressing the NF-κB pathway in human dermal fibroblasts

Title
Brazilin inhibits UVB-induced MMP-1/3 expressions and secretions by suppressing the NF-κB pathway in human dermal fibroblasts
Authors
Lee Y.-R.Noh E.-M.Han J.-H.Kim J.-M.Hwang J.-K.Hwang B.-M.Chung E.-Y.Kim B.-S.Lee S.-H.Lee S.J.Kim J.-S.
Ewha Authors
이승진
SCOPUS Author ID
이승진scopus
Issue Date
2012
Journal Title
European Journal of Pharmacology
ISSN
0014-2999JCR Link
Citation
vol. 674, no. 41308, pp. 80 - 86
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Brazilin (7, 11b-dihydrobenz[b]indeno[1,2-d]pyran-3,6a,9,10 (6H)-tetrol), the major component of Caesalpinia sappan L., is a natural red pigment used for histological staining. Recent studies have shown that brazilin exhibits distinct biological effects, including anti-hepatotoxicity, antiplatelet activity, and anti-inflammatory activities. In the present study, we evaluated the effects of brazilin on MMP-1 and -3 expressions in human dermal fibroblasts exposed to ultraviolet B (UVB) irradiation. Brazilin showed protective effect on UVB-induced loss of cell viability of fibroblasts. Brazilin also blocked significantly UVB-induced Reactive Oxygen Species generation in fibroblasts. Brazilin inhibited UVB-induced MMP-1/3 expressions and secretions in a dose-dependent manner. Moreover, UVB-induced NF-κB activation was completely blocked by treatment with brazilin. These findings suggest that brazilin inhibits UVB-induced MMP-1/3 expressions and secretions by suppressing of NF-κB activation in human dermal fibroblasts. Thus, brazilin might be used as a potential agent for treatment of UV-induced skin photoaging. © 2011 Elsevier B.V. All rights reserved.
DOI
10.1016/j.ejphar.2011.10.016
Appears in Collections:
약학대학 > 약학과 > Journal papers
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