Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 정화순 | * |
dc.contributor.author | 성주명 | * |
dc.contributor.author | 허정원 | * |
dc.contributor.author | 문영철 | * |
dc.date.accessioned | 2016-08-28T12:08:53Z | - |
dc.date.available | 2016-08-28T12:08:53Z | - |
dc.date.issued | 2011 | * |
dc.identifier.issn | 2210-7762 | * |
dc.identifier.other | OAK-8440 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/222337 | - |
dc.description.abstract | Single nucleotide polymorphism array (SNP-A)-based karyotyping can identify copy-neutral loss of heterozygosity (CN-LOH) as well as cryptic lesions not detected by metaphase cytogenetics. We report serial genetic studies on a patient diagnosed with chronic myelomonocytic leukemia who progressed to acute leukemia. Monosomy 7 was predominantly found at diagnosis, but clones changed to CN-LOH of chromosome 7 with disease progression. Furthermore, subclones with genomic aberrations of 3q gain, 1. p CN-LOH, and trisomy 12 newly appeared, suggesting that they were also involved in the transformation process. Additionally, by SNP-A, a presumably balanced translocation, t(14;20), identified by metaphase cytogenetics, was shown to result in an unbalanced 20q deletion at the breakpoint. The sequential changes identified by SNP-A may provide a better understanding of the mechanism of clonal evolution. © 2011 Elsevier Inc. | * |
dc.language | English | * |
dc.title | Single nucleotide polymorphism array-based karyotyping shows sequential genomic changes from monosomy to copy-neutral loss of heterozygosity of chromosome 7 and 20q deletion within a balanced translocation t(14;20) in AML | * |
dc.type | Article | * |
dc.relation.issue | 12 | * |
dc.relation.volume | 204 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 682 | * |
dc.relation.lastpage | 686 | * |
dc.relation.journaltitle | Cancer Genetics | * |
dc.identifier.doi | 10.1016/j.cancergen.2011.11.003 | * |
dc.identifier.wosid | WOS:000300033600007 | * |
dc.identifier.scopusid | 2-s2.0-84858778355 | * |
dc.author.google | Huh J. | * |
dc.author.google | Mun Y.C. | * |
dc.author.google | Seong C.M. | * |
dc.author.google | Chung W.S. | * |
dc.contributor.scopusid | 정화순(7401983201;54885771500) | * |
dc.contributor.scopusid | 성주명(7005537065) | * |
dc.contributor.scopusid | 허정원(7102258576) | * |
dc.contributor.scopusid | 문영철(7003363716) | * |
dc.date.modifydate | 20240422115947 | * |