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Innate immune system gene polymorphisms in maternal and child genotype and risk of preterm delivery
- Title
- Innate immune system gene polymorphisms in maternal and child genotype and risk of preterm delivery
- Authors
- Jones N.M.; Holzman C.; Tian Y.; Witkin S.S.; Genc M.; Friderici K.; Fisher R.; Sezen D.; Babula O.; Jernigan K.A.; Chung H.; Wirth J.
- Ewha Authors
- 정환
- SCOPUS Author ID
- 정환
- Issue Date
- 2012
- Journal Title
- Journal of Maternal-Fetal and Neonatal Medicine
- ISSN
- 1476-7058
- Citation
- Journal of Maternal-Fetal and Neonatal Medicine vol. 25, no. 3, pp. 240 - 247
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Objective.There is little information about the combination of genetic variability in pregnant women and their children in relation to the risk of preterm delivery (PTD). In a sub-cohort of 487 non-Hispanic white and 288 African-American mother/child pairs, the Pregnancy Outcomes and Community Health Study assessed 10 functional polymorphisms in 9 genes involved in innate immune function. Methods.Race-stratified weighted logistic regression models were used to calculate odds ratios for genotype and PTD/PTD subtypes. Polymorphisms significantly associated with PTD/PTD subtypes were tested for mother/child genotype interactions. Results.Three maternal polymorphisms (IL-1 receptor antagonist intron two repeat (IL-1RN), matrix metalloproteinase-C1562T, and TNF receptor two M196R (TNFR2)) and three child polymorphisms (IL1-RN, tumor necrosis factor-alpha-G308A, and TNFR2) were associated with PTD, but associations varied by PTD subtype and race. Two interactions were detected for maternal and child genotype. Among non-Hispanic white women, the odds of PTD was higher when both mother and child carried the IL-1RN allele two (additive interaction p < 0.05). Among African-American women, the odds of PTD were higher when both mother and child carried the TNFR2 R allele (multiplicative interaction p < 0.05). Conclusion.These results highlight the importance of assessing both maternal and child genotype in relation to PTD risk. © 2012 Informa UK, Ltd.
- DOI
- 10.3109/14767058.2011.569614
- Appears in Collections:
- 자연과학대학 > 통계학전공 > Journal papers
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