Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 오세관 | * |
dc.date.accessioned | 2016-08-28T12:08:51Z | - |
dc.date.available | 2016-08-28T12:08:51Z | - |
dc.date.issued | 2012 | * |
dc.identifier.issn | 1420-3049 | * |
dc.identifier.other | OAK-8403 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/222311 | - |
dc.description.abstract | A simple and efficient seven steps synthesis of brodifacoum and difethialone from phenylacetyl chloride is described. The key synthetic strategies involve Friedel-Crafts acylation, intramolecular ring cyclization and condensation reaction in the presence of Brønsted-Lowry acids. It was found that brodifacoum showed favorable inhibiting activities on LPS-stimulated nitrite production in BV-2 microglia cells. Brodifacoum exhibited superior anti-inflammatory effects than difethialone. We expect that an efficient linear synthesis of 4-hydroxycoumarin derivatives and key fragments that are useful agents for the modulation of inflammation as well as inhibition of coagulation will be of practical use. © 2012 by the authors. | * |
dc.language | English | * |
dc.title | Practical synthesis of hydroxychromenes and evaluation of their biological activity | * |
dc.type | Article | * |
dc.relation.issue | 1 | * |
dc.relation.volume | 17 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 240 | * |
dc.relation.lastpage | 247 | * |
dc.relation.journaltitle | Molecules | * |
dc.identifier.doi | 10.3390/molecules17010240 | * |
dc.identifier.wosid | WOS:000299535700015 | * |
dc.identifier.scopusid | 2-s2.0-84856143292 | * |
dc.author.google | Jung J.-C. | * |
dc.author.google | Oh S. | * |
dc.contributor.scopusid | 오세관(7404103757) | * |
dc.date.modifydate | 20240118133340 | * |