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Reference values for serum levels of insulin-like growth factor-I and insulin-like growth factor binding protein-3 in Korean children and adolescents
- Reference values for serum levels of insulin-like growth factor-I and insulin-like growth factor binding protein-3 in Korean children and adolescents
- Hyun S.E.; Lee B.C.; Suh B.K.; Chung S.C.; Ko C.W.; Kim H.S.; Lee K.H.; Yang S.W.; Shin C.H.; Hwang J.S.; Kim D.H.; Lim B.K.; Kim J.D.; Yoo H.-W.; Chung W.Y.; Park M.J.; Woo Y.J.; Kim C.J.; Lee D.-Y.; Kim E.Y.; Choi J.H.; Han H.S.; Hwang I.T.; Kim H.-S.
- Ewha Authors
- SCOPUS Author ID
- Issue Date
- Journal Title
- Clinical Biochemistry
- vol. 45, no. 41276, pp. 16 - 21
- SCI; SCIE; SCOPUS
- Objective: Measurements of serum insulin-like growth factor-I (IGF-I) and IGF binding protein-3 (IGFBP-3) are utilized in the diagnostic work-up and clinical management of children with growth disorders. We designed this study to establish the reference values of serum IGF-I and IGFBP-3 levels according to age, sex and pubertal stage in Korean children and adolescents. Methods: For the study, 1378 healthy Korean children and adolescents aged 0 to 17. years (722 boys, 656 girls) were randomly selected. Blood samples were collected, and the stored sera were assayed for IGF-I and IGFBP-3 using immunoradiometric assay (IRMA, Immunotech). The R 2.8.1 program (Bell Laboratories) was used to generate reference percentile curves for IGF-I and IGFBP-3 according to age, sex, and pubertal stage. Results: Serum IGFBP-3 level was higher in girls compared to that in boys of the same ages throughout the pubertal period, whereas IGF-I was only higher for girls younger than 13. years of age. Serum levels of IGF-I and IGFBP-3 increased steadily with age in the prepubertal stage, followed by a progressive decline thereafter. Peak levels of serum IGF-I and IGFBP-3 were observed two years earlier in girls compared to those in boys (13 vs. 15. years of age, respectively). Serum IGF-I and IGFBP-3 concentrations were highest at Tanner stage IV in boys and girls, with a subsequent decline. Conclusions: Our reference value model based on age, sex, and pubertal stage can improve the diagnostic utility of IGF-1 and IGFBP-3 levels in the evaluation and management of Korean children and adolescents with growth disorders. © 2011.
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