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Reference values for serum levels of insulin-like growth factor-I and insulin-like growth factor binding protein-3 in Korean children and adolescents

Title
Reference values for serum levels of insulin-like growth factor-I and insulin-like growth factor binding protein-3 in Korean children and adolescents
Authors
Hyun S.E.Lee B.C.Suh B.K.Chung S.C.Ko C.W.Kim H.S.Lee K.H.Yang S.W.Shin C.H.Hwang J.S.Kim D.H.Lim B.K.Kim J.D.Yoo H.-W.Chung W.Y.Park M.J.Woo Y.J.Kim C.J.Lee D.-Y.Kim E.Y.Choi J.H.Han H.S.Hwang I.T.Kim H.-S.
Ewha Authors
김혜순
SCOPUS Author ID
김혜순scopus
Issue Date
2012
Journal Title
Clinical Biochemistry
ISSN
0009-9120JCR Link
Citation
vol. 45, no. 41276, pp. 16 - 21
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Objective: Measurements of serum insulin-like growth factor-I (IGF-I) and IGF binding protein-3 (IGFBP-3) are utilized in the diagnostic work-up and clinical management of children with growth disorders. We designed this study to establish the reference values of serum IGF-I and IGFBP-3 levels according to age, sex and pubertal stage in Korean children and adolescents. Methods: For the study, 1378 healthy Korean children and adolescents aged 0 to 17. years (722 boys, 656 girls) were randomly selected. Blood samples were collected, and the stored sera were assayed for IGF-I and IGFBP-3 using immunoradiometric assay (IRMA, Immunotech). The R 2.8.1 program (Bell Laboratories) was used to generate reference percentile curves for IGF-I and IGFBP-3 according to age, sex, and pubertal stage. Results: Serum IGFBP-3 level was higher in girls compared to that in boys of the same ages throughout the pubertal period, whereas IGF-I was only higher for girls younger than 13. years of age. Serum levels of IGF-I and IGFBP-3 increased steadily with age in the prepubertal stage, followed by a progressive decline thereafter. Peak levels of serum IGF-I and IGFBP-3 were observed two years earlier in girls compared to those in boys (13 vs. 15. years of age, respectively). Serum IGF-I and IGFBP-3 concentrations were highest at Tanner stage IV in boys and girls, with a subsequent decline. Conclusions: Our reference value model based on age, sex, and pubertal stage can improve the diagnostic utility of IGF-1 and IGFBP-3 levels in the evaluation and management of Korean children and adolescents with growth disorders. © 2011.
DOI
10.1016/j.clinbiochem.2011.10.003
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의학전문대학원 > 의학과 > Journal papers
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