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의과대학
의학과
Journal papers
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Relationship between body-mass index and serum folate concentrations in pregnant women
Title
Relationship between body-mass index and serum folate concentrations in pregnant women
Authors
Kim H.
;
Hwang J.-Y.
;
Kim K.-N.
;
Ha E.-H.
;
Park H.
;
Ha M.
;
Lee K.-Y.
;
Hong Y.-C.
;
Tamura T.
;
Chang N.
Ewha Authors
하은희
;
장남수
;
박혜숙
;
김혜숙
SCOPUS Author ID
하은희
; 장남수
; 박혜숙
; 김혜숙
Issue Date
2012
Journal Title
European Journal of Clinical Nutrition
ISSN
0954-3007
Citation
European Journal of Clinical Nutrition vol. 66, no. 1, pp. 136 - 138
Indexed
SCI; SCIE; SCOPUS
Document Type
Article
Abstract
The concentration of micronutrients impacts fetal development and pregnancy outcome and has been suggested to be negatively correlated with the body-mass index (BMI). We evaluated the relationship between BMI and the serum folate concentration in 802 and 660 Korean pregnant women in mid- and late pregnancy, respectively, who participated in a multicenter prospective study. There was a significant negative correlation between BMI value and the serum folate concentration at mid- and late pregnancy (P for trend 0.001 and 0.024, respectively). A general linear model confirmed this correlation at both time points after adjusting for gestational age and total folate intake. These findings are important as the serum folate concentration is a rate-limiting factor for placental folate transport to the fetus, and an inadequate folate supply may cause various malformations. © 2012 Macmillan Publishers Limited All rights reserved.
DOI
10.1038/ejcn.2011.160
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