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Relationship between body-mass index and serum folate concentrations in pregnant women

Title
Relationship between body-mass index and serum folate concentrations in pregnant women
Authors
Kim H.Hwang J.-Y.Kim K.-N.Ha E.-H.Park H.Ha M.Lee K.-Y.Hong Y.-C.Tamura T.Chang N.
Ewha Authors
하은희장남수박혜숙김혜숙
SCOPUS Author ID
하은희scopus; 장남수scopus; 박혜숙scopus; 김혜숙scopus
Issue Date
2012
Journal Title
European Journal of Clinical Nutrition
ISSN
0954-3007JCR Link
Citation
vol. 66, no. 1, pp. 136 - 138
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The concentration of micronutrients impacts fetal development and pregnancy outcome and has been suggested to be negatively correlated with the body-mass index (BMI). We evaluated the relationship between BMI and the serum folate concentration in 802 and 660 Korean pregnant women in mid- and late pregnancy, respectively, who participated in a multicenter prospective study. There was a significant negative correlation between BMI value and the serum folate concentration at mid- and late pregnancy (P for trend 0.001 and 0.024, respectively). A general linear model confirmed this correlation at both time points after adjusting for gestational age and total folate intake. These findings are important as the serum folate concentration is a rate-limiting factor for placental folate transport to the fetus, and an inadequate folate supply may cause various malformations. © 2012 Macmillan Publishers Limited All rights reserved.
DOI
10.1038/ejcn.2011.160
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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