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Induction of remission is difficult due to frequent relapse during tapering steroids in Korean patients with polymyalgia rheumatica

Title
Induction of remission is difficult due to frequent relapse during tapering steroids in Korean patients with polymyalgia rheumatica
Authors
Kim H.-A.Lee J.Ha Y.-J.Kim S.-H.Lee C.-H.Choi H.-J.Baek H.-J.Lim M.J.Park W.Choi S.Hong Y.-S.Lee Y.-H.Koh B.-R.Suh C.-H.
Ewha Authors
이지수
SCOPUS Author ID
이지수scopus
Issue Date
2012
Journal Title
Journal of Korean Medical Science
ISSN
1011-8934JCR Link
Citation
vol. 27, no. 1, pp. 22 - 26
Indexed
SCI; SCIE; SCOPUS; KCI WOS scopus
Abstract
Polymyalgia rheumatica is an inflammatory disease affecting elderly and involving the shoulder and pelvic girdles. No epidemiological study of polymyalgia rheumatica was conducted in Korea. We retrospectively evaluated patients with polymyalgia rheumatica followed up at the rheumatology clinics of 10 tertiary hospitals. In total 51 patients, 36 patients (70.6%) were female. Age at disease onset was 67.4 yr. Twenty-three patients (45.1%) developed polymyalgia rheumatica in winter. Shoulder girdle ache was observed in 45 patients (90%) and elevated erythrocyte sedimentation rate (> 40 mm/h) in 49 patients (96.1%). Initial steroid dose was 23.3 mg/d prednisolone equivalent. Time to normal erythrocyte sedimentation rate was 4.1 months. Only 8 patients (15.7%) achieved remission. Among 41 patients followed up, 28 patients (68.3%) had flare at least once. Number of flares was 1.5 ± 1.6. The frequency of flare was significantly lower in patients with remission (P = 0.02). In Korea, polymyalgia rheumatica commonly develops during winter. Initial response to steroid is fairly good, but the prognosis is not benign because remission is rare with frequent relapse requiring long-term steroid treatment. © 2012 The Korean Academy of Medical Sciences.
DOI
10.3346/jkms.2012.27.1.22
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의학전문대학원 > 의학과 > Journal papers
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