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Inhibition of matrix metalloproteinase-1 induced by oxidative stress in human keratinocytes by mangiferin isolated from Anemarrhena asphodeloides

Title
Inhibition of matrix metalloproteinase-1 induced by oxidative stress in human keratinocytes by mangiferin isolated from Anemarrhena asphodeloides
Authors
Chae S.Piao M.J.Kang K.A.Zhang R.Kim K.C.Youn U.J.Nam K.-W.Lee J.H.Hyun J.W.
Ewha Authors
윤의중
Issue Date
2011
Journal Title
Bioscience, Biotechnology and Biochemistry
ISSN
0916-8451JCR Link
Citation
vol. 75, no. 12, pp. 2321 - 2325
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Oxidative stress is related to the synthesis of matrix metalloproteinases (MMPs), which cause skin aging. The protective effects of mangiferin derived from Anemarrhena asphodeloides were investigated against hydrogen peroxide (H 2O 2)-induced damage using human skin keratinocyte (HaCaT) cells. Mangiferin was found to scavenge intracellular reactive oxygen species (ROS), superoxide radicals, and hydroxyl radicals. ROS regulate MMPs gene expression and activation of proenzymes. Mangiferin inhibited H 2O 2-induced MMP-1 gene expression and protein levels as well as its activity. Moreover, it abrogated mitogen-activated protein kinase kinase (MEK)-extracellular signal-regulated kinase (ERK) pathway and stress-activated protein kinase/extracellular signal-regulated kinase (SEK)-c-JUN N-terminal kinase (JNK) pathway, which are induced by H 2O 2 treatment. And, it inhibited DNA binding activity of activator protein-1 (AP-1), a transcription factor of MMP-1 and downstream of ERK and JNK. Finally, it protected the human skin keratinocytes from H 2O 2-induced cell death. Taken together, these results indicate that mangiferin attenuated H 2O 2-induced MMP-1 activation via inhibition of ERK and JNK pathway and AP-1.
DOI
10.1271/bbb.110465
Appears in Collections:
연구기관 > 약학연구소 > Journal papers
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