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Regulation of reactive oxygen species generation in cell signaling

Title
Regulation of reactive oxygen species generation in cell signaling
Authors
Bae Y.S.Oh H.Rhee S.G.Yoo Y.D.
Ewha Authors
이서구배윤수
SCOPUS Author ID
이서구scopusscopus; 배윤수scopus
Issue Date
2011
Journal Title
Molecules and Cells
ISSN
1016-8478JCR Link
Citation
vol. 32, no. 6, pp. 491 - 509
Indexed
SCI; SCIE; SCOPUS; KCI WOS scopus
Abstract
Reactive oxygen species (ROS) including superoxide anion and hydrogen peroxide (H2O2) are thought to be byproducts of aerobic respiration with damaging effects on DNA, protein, and lipid. A growing body of evidence indicates, however, that ROS are involved in the maintenance of redox homeostasis and various cellular signaling pathways. ROS are generated from diverse sources including mitochondrial respiratory chain, enzymatic activation of cytochrome p450, and NADPH oxidases further suggesting involvement in a complex array of cellular processes. This review summarizes the production and function of ROS. In particular, how cytosolic and membrane proteins regulate ROS generation for intracellular redox signaling will be detailed. © 2011 KSMCB.
DOI
10.1007/s10059-011-0276-3
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일반대학원 > 생명·약학부 > Journal papers
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