View : 21 Download: 8

Convenient synthesis and biological evaluation of modafinil derivatives: Benzhydrylsulfanyl and benzhydrylsulfinyl [1,2,3]triazol-4-yl-methyl esters

Title
Convenient synthesis and biological evaluation of modafinil derivatives: Benzhydrylsulfanyl and benzhydrylsulfinyl [1,2,3]triazol-4-yl-methyl esters
Authors
Jung J.-C.Lee Y.Son J.-Y.Lim E.Jung M.Oh S.
Ewha Authors
오세관정재철
SCOPUS Author ID
오세관scopus
Issue Date
2011
Journal Title
Molecules
ISSN
1420-3049JCR Link
Citation
vol. 16, no. 12, pp. 10409 - 10419
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Simple synthesis and biological activities of modafinil derivatives are described. The key reactions include condensation of acid and propargyl alcohol, subsequent 1,3-dipolar cycloaddition reaction of alkynes and (3-azido-propyl)cyclohexane or (4-azidobutyl) benzene in the presence of sodium ascorbate and CuSO 4·5H 2O in excellent yield. They were then evaluated for the suppression of LPS-induced NO generation in vitro. It was found that all compounds showed moderate effects for suppression of LPS-induced NO generation. © 2011 by the authors; licensee MDPI, Basel, Switzerland.
DOI
10.3390/molecules161210409
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
Files in This Item:
001.pdf(203.99 kB)Download
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE