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Convenient synthesis and biological evaluation of modafinil derivatives: Benzhydrylsulfanyl and benzhydrylsulfinyl [1,2,3]triazol-4-yl-methyl esters
- Title
- Convenient synthesis and biological evaluation of modafinil derivatives: Benzhydrylsulfanyl and benzhydrylsulfinyl [1,2,3]triazol-4-yl-methyl esters
- Authors
- Jung J.-C.; Lee Y.; Son J.-Y.; Lim E.; Jung M.; Oh S.
- Ewha Authors
- 오세관; 정재철
- SCOPUS Author ID
- 오세관; 정재철
- Issue Date
- 2011
- Journal Title
- Molecules
- ISSN
- 1420-3049
- Citation
- Molecules vol. 16, no. 12, pp. 10409 - 10419
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Simple synthesis and biological activities of modafinil derivatives are described. The key reactions include condensation of acid and propargyl alcohol, subsequent 1,3-dipolar cycloaddition reaction of alkynes and (3-azido-propyl)cyclohexane or (4-azidobutyl) benzene in the presence of sodium ascorbate and CuSO 4·5H 2O in excellent yield. They were then evaluated for the suppression of LPS-induced NO generation in vitro. It was found that all compounds showed moderate effects for suppression of LPS-induced NO generation. © 2011 by the authors; licensee MDPI, Basel, Switzerland.
- DOI
- 10.3390/molecules161210409
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
- Files in This Item:
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