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Post-translational modifications of mitochondrial aldehyde dehydrogenase and biomedical implications

Title
Post-translational modifications of mitochondrial aldehyde dehydrogenase and biomedical implications
Authors
Song B.-J.Abdelmegeed M.A.Yoo S.-H.Kim B.-J.Jo S.A.Jo I.Moon K.-H.
Ewha Authors
조인호
SCOPUS Author ID
조인호scopus
Issue Date
2011
Journal Title
Journal of Proteomics
ISSN
1874-3919JCR Link
Citation
vol. 74, no. 12, pp. 2691 - 2702
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Aldehyde dehydrogenases (ALDHs) represent large family members of NAD(P)+-dependent dehydrogenases responsible for the irreversible metabolism of many endogenous and exogenous aldehydes to the corresponding acids. Among 19 ALDH isozymes, mitochondrial ALDH2 is a low Km enzyme responsible for the metabolism of acetaldehyde and lipid peroxides such as malondialdehyde and 4-hydroxynonenal, both of which are highly reactive and toxic. Consequently, inhibition of ALDH2 would lead to elevated levels of acetaldehyde and other reactive lipid peroxides following ethanol intake and/or exposure to toxic chemicals. In addition, many East Asian people with a dominant negative mutation in ALDH2 gene possess a decreased ALDH2 activity with increased risks for various types of cancer, myocardial infarct, alcoholic liver disease, and other pathological conditions. The aim of this review is to briefly describe the multiple post-translational modifications of mitochondrial ALDH2, as an example, after exposure to toxic chemicals or under different disease states and their pathophysiological roles in promoting alcohol/drug-mediated tissue damage. We also briefly mention exciting preclinical translational research opportunities to identify small molecule activators of ALDH2 and its isozymes as potentially therapeutic/preventive agents against various disease states where the expression or activity of ALDH enzymes is altered or inactivated. © 2011.
DOI
10.1016/j.jprot.2011.05.013
Appears in Collections:
의과대학 > 의학과 > Journal papers
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