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Adverse prognostic impact of abnormal lesions detected by genome-wide single nucleotide polymorphism array-based karyotyping analysis in acute myeloid leukemia with normal karyotype

Title
Adverse prognostic impact of abnormal lesions detected by genome-wide single nucleotide polymorphism array-based karyotyping analysis in acute myeloid leukemia with normal karyotype
Authors
Yi J.H.Huh J.Kim H.-J.Kim S.-H.Kim Y.-K.Sohn S.K.Moon J.H.Kim S.H.Kim K.H.Won J.H.Mun Y.C.Kim H.Park J.Jung C.W.Kim D.H.
Ewha Authors
허정원문영철
SCOPUS Author ID
허정원scopus; 문영철scopus
Issue Date
2011
Journal Title
Journal of Clinical Oncology
ISSN
0732-183XJCR Link
Citation
vol. 29, no. 35, pp. 4702 - 4708
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Purpose: This study attempted to analyze the prognostic role of single nucleotide polymorphism array (SNP-A) -based karyotying in 133 patients with acute myeloid leukemia with normal karyotype (AML-NK), which presents with diverse clinical outcomes, thus requiring further stratification of patient subgroups according to their prognoses. Patients and Methods: A total of 133 patients with AML-NK confirmed by metaphase cytogenetics (MC) and fluorescent in situ hybridization analysis were included in this study. Analysis by Genome-Wide Human SNP 6.0 Array was performed by using DNAs derived from marrow samples at diagnosis. Results: Forty-three patients (32.3%) had at least one abnormal SNP lesion that was not detected by MC. One hundred thirteen abnormal SNP lesions included 55 losses, 23 gains, and 35 copy-neutral losses of heterozygosity. Multivariate analyses showed that detection of abnormal SNP lesions by SNP-A karyotyping results in an unfavorable prognostic value for overall survival (hazard ratio [HR], 2.69; 95% CI, 1.50 to 4.82; P = .001); other significant prognostic factors included secondary AML (HR, 5.55; 95% CI, 1.80 to 17.14; P = .003), presence of the FLT3 mutation (HR, 3.17; 95% CI, 1.71 to 5.87; P < .001), and age (HR, 1.03; 95% CI, 1.01 to 1.05; P = .020). Conclusion: Our data demonstrated that abnormal SNP lesions detected by SNP-A karyotyping might indicate an adverse prognosis in patients with AML-NK, thus requiring a more sophisticated treatment strategy for improvement of treatment outcomes. © 2011 by American Society of Clinical Oncology.
DOI
10.1200/JCO.2011.35.5719
Appears in Collections:
의과대학 > 의학과 > Journal papers
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