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Prediction of pneumococcal conjugate vaccine effectiveness against invasive pneumococcal disease using opsonophagocytic activity and antibody concentrations determined by enzyme-linked immunosorbent assay with 22F adsorption

Title
Prediction of pneumococcal conjugate vaccine effectiveness against invasive pneumococcal disease using opsonophagocytic activity and antibody concentrations determined by enzyme-linked immunosorbent assay with 22F adsorption
Authors
Schuerman L.Wysocki J.Tejedor J.C.Knuf M.Kim K.-H.Poolman J.
Ewha Authors
김경효
SCOPUS Author ID
김경효scopus
Issue Date
2011
Journal Title
Clinical and Vaccine Immunology
ISSN
1556-6811JCR Link
Citation
Clinical and Vaccine Immunology vol. 18, no. 12, pp. 2161 - 2167
Indexed
SCI; SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
We compared the abilities of two serological readouts, antipolysaccharide IgG antibody concentrations and opsonophagocytic activity (OPA) titers, to predict the clinical effectiveness of the 7-valent pneumococcal conjugate vaccine (7vCRM) against invasive pneumococcal disease (IPD). We also assessed the accuracy of the previously established thresholds for GlaxoSmithKline's enzyme-linked immunosorbent assay with 22F adsorption (22F-ELISA) (≥0.2 μg/ml) and OPA assay (titer, ≥8) in predicting effectiveness. We showed that following a 3-dose 7vCRM primary vaccination, the serological response rates as determined using thresholds of ≥0.2 μg/ml IgG and an OPA titer of ≥8 corresponded well with overall effectiveness against IPD. In addition, the OPA assay seemed to better predict serotype-specific effectiveness than enzyme-linked immunoassay. Finally, when applied to post-dose-2 immune responses, both thresholds also corresponded well with the overall IPD effectiveness following a 2-dose 7vCRM primary vaccination. These results support the importance of the OPA assay in evaluating immune responses to pneumococcal conjugate vaccines. Copyright © 2011 American Society for Microbiology. All Rights Reserved.
DOI
10.1128/CVI.05313-11
Appears in Collections:
의과대학 > 의학과 > Journal papers
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