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Prediction of pneumococcal conjugate vaccine effectiveness against invasive pneumococcal disease using opsonophagocytic activity and antibody concentrations determined by enzyme-linked immunosorbent assay with 22F adsorption

Title
Prediction of pneumococcal conjugate vaccine effectiveness against invasive pneumococcal disease using opsonophagocytic activity and antibody concentrations determined by enzyme-linked immunosorbent assay with 22F adsorption
Authors
Schuerman L.Wysocki J.Tejedor J.C.Knuf M.Kim K.-H.Poolman J.
Ewha Authors
김경효
SCOPUS Author ID
김경효scopus
Issue Date
2011
Journal Title
Clinical and Vaccine Immunology
ISSN
1556-6811JCR Link
Citation
vol. 18, no. 12, pp. 2161 - 2167
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
We compared the abilities of two serological readouts, antipolysaccharide IgG antibody concentrations and opsonophagocytic activity (OPA) titers, to predict the clinical effectiveness of the 7-valent pneumococcal conjugate vaccine (7vCRM) against invasive pneumococcal disease (IPD). We also assessed the accuracy of the previously established thresholds for GlaxoSmithKline's enzyme-linked immunosorbent assay with 22F adsorption (22F-ELISA) (≥0.2 μg/ml) and OPA assay (titer, ≥8) in predicting effectiveness. We showed that following a 3-dose 7vCRM primary vaccination, the serological response rates as determined using thresholds of ≥0.2 μg/ml IgG and an OPA titer of ≥8 corresponded well with overall effectiveness against IPD. In addition, the OPA assay seemed to better predict serotype-specific effectiveness than enzyme-linked immunoassay. Finally, when applied to post-dose-2 immune responses, both thresholds also corresponded well with the overall IPD effectiveness following a 2-dose 7vCRM primary vaccination. These results support the importance of the OPA assay in evaluating immune responses to pneumococcal conjugate vaccines. Copyright © 2011 American Society for Microbiology. All Rights Reserved.
DOI
10.1128/CVI.05313-11
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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