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Comparison of clinico-physiologic and CT imaging risk factors for COPD exacerbation

Title
Comparison of clinico-physiologic and CT imaging risk factors for COPD exacerbation
Authors
Yoo J.-W.Hong Y.Seo J.B.Chae E.J.Ra S.W.Lee J.-H.Kim E.K.Baek S.Kim T.-H.Kim W.J.Lee J.H.Lee S.-M.Lee S.Lim S.Y.Shin T.R.Yoon H.I.Sheen S.S.Lee J.S.Huh J.W.Oh Y.-M.Lee S.-D.
Ewha Authors
이진화
SCOPUS Author ID
이진화scopus
Issue Date
2011
Journal Title
Journal of Korean Medical Science
ISSN
1011-8934JCR Link
Citation
vol. 26, no. 12, pp. 1606 - 1612
Indexed
SCI; SCIE; SCOPUS; KCI WOS scopus
Abstract
To date, clinico-physiologic indices have not been compared with quantitative CT imaging indices in determining the risk of chronic obstructive pulmonary disease (COPD) exacerbation. We therefore compared clinico-physiologic and CT imaging indices as risk factors for COPD exacerbation in patients with COPD. We retrospectively analyzed 260 COPD patients from pulmonary clinics at 11 hospitals in Korea from June 2005 to November 2009 and followed-up for at least one year. At the time of enrollment, none of these patients had COPD exacerbations for at least 2 months. All underwent clinico-physiologic and radiological evaluation for risk factors of COPD exacerbation. After 1 yr, 106 of the 260 patients had at least one exacerbation of COPD. Multiple logistic regression analysis showed that old age, high Charlson Index, and low FEV1 were significant in a clinico-physiologic model, with C-statistics of 0.69, and that increased age and emphysema index were significant in a radiologic model, with C-statistics of 0.64. The difference between the two models was statistically significant (P = 0.04 by bootstrap analysis). Combinations of clinico-physiologic risk factors may be better than those of imaging risk factors in predicting COPD exacerbation. © 2011 The Korean Academy of Medical Sciences.
DOI
10.3346/jkms.2011.26.12.1606
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의과대학 > 의학과 > Journal papers
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