View : 137 Download: 0

Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease

Title
Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease
Authors
Khor C.C.Davila S.Breunis W.B.Lee Y.-C.Shimizu C.Wright V.J.Yeung R.S.M.Tan D.E.K.Sim K.S.Wang J.J.Wong T.Y.Pang J.Mitchell P.Cimaz R.Dahdah N.Cheung Y.-F.Huang G.-Y.Yang W.Park I.-S.Lee J.-K.Wu J.-Y.Levin M.Burns J.C.Burgner D.Kuijpers T.W.Hibberd M.L.Lau Y.-L.Zhang J.Ma X.-J.Liu F.Wu L.Yoo J.-J.Hong S.-J.Kim K.-J.Kim J.-J.Park Y.-M.Hong Y.M.Sohn S.Jang G.Y.Ha K.-S.Nam H.-K.Byeon J.-H.Yun S.W.Han M.K.Lee K.-Y.Hwang J.-Y.Rhim J.-W.Song M.S.Lee H.-D.Kim D.S.Lee J.-M.Chang J.-S.Tsai F.-J.Liang C.-D.Chen M.-R.Chi H.Chiu N.-C.Huang F.-Y.Chang L.-Y.Huang L.-M.Kuo H.-C.Huang K.-P.Lee M.-L.Hwang B.Huang Y.-C.Lee P.-C.Odam M.Christiansen F.T.Witt C.Goldwater P.Curtis N.Palasanthiran P.Ziegler J.Nissen M.Nourse C.Kuipers I.M.Ottenkamp J.J.Geissler J.Biezeveld M.Tacke C.Filippini L.Brogan P.Klein N.Shah V.Dillon M.Booy R.Shingadia D.Bose A.Mukasa T.Tulloh R.Michie C.Newburger J.W.Baker A.L.Rowley A.H.Shulman S.T.Mason W.Takahashi M.Melish M.E.Tremoulet A.H.Viswanathan A.Rochtchina E.Attia J.Scott R.Holliday E.Harrap S.
Ewha Authors
홍영미손세정
SCOPUS Author ID
홍영미scopus; 손세정scopus
Issue Date
2011
Journal Title
Nature Genetics
ISSN
1061-4036JCR Link
Citation
Nature Genetics vol. 43, no. 12, pp. 1241 - 1246
Indexed
SCI; SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Kawasaki disease is a systemic vasculitis of unknown etiology, with clinical observations suggesting a substantial genetic contribution to disease susceptibility. We conducted a genome-wide association study and replication analysis in 2,173 individuals with Kawasaki disease and 9,383 controls from five independent sample collections. Two loci exceeded the formal threshold for genome-wide significance. The first locus is a functional polymorphism in the IgG receptor gene FCGR2A (encoding an H131R substitution) (rs1801274; P = 7.35 × 10 -11, odds ratio (OR) = 1.32), with the A allele (coding for histadine) conferring elevated disease risk. The second locus is at 19q13, (P = 2.51 × 10 -9, OR = 1.42 for the rs2233152 SNP near MIA and RAB4B; P = 1.68 × 10 -12, OR = 1.52 for rs28493229 in ITPKC), which confirms previous findings. The involvement of the FCGR2A locus may have implications for understanding immune activation in Kawasaki disease pathogenesis and the mechanism of response to intravenous immunoglobulin, the only proven therapy for this disease. © 2011 Nature America, Inc. All rights reserved.
DOI
10.1038/ng.981
Appears in Collections:
의과대학 > 의학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE