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dc.contributor.author김경효-
dc.date.accessioned2017-08-28T22:06:45Z-
dc.date.available2017-08-28T22:06:45Z-
dc.date.issued2011-
dc.identifier.issn0891-3668-
dc.identifier.otherOAK-8192-
dc.identifier.urihttp://dspace.ewha.ac.kr/handle/2015.oak/222127-
dc.description.abstractBackground: This randomized single-blind study in Korea evaluated noninferiority of the 10-valent pneumococcal nontypeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) versus the 7-valent pneumococcal conjugate vaccine (7vCRM) when both were coadministered with H. influenzae type b (Hib) conjugate vaccine, as opposed to coadministration with diphtheria-tetanus- acellular pertussis-based combination vaccines in previous studies. Methods: Infants received 3 primary doses at 2, 4, and 6 months and a booster dose at 12 to 18 months of PHiD-CV (N = 374) or 7vCRM (N = 129), both coadministered with Hib vaccine. Immune responses were measured 1 month postdose 3 and postbooster using 22F-inhibition enzyme-linked immunosorbent assay and functional opsonophagocytic activity assay. Results: PHiD-CV-induced antibody responses against each of the vaccine pneumococcal serotypes and protein D. Noninferiority to 7vCRM was demonstrated for all 10 PHiD-CV serotypes in terms of percentages of subjects reaching an antibody concentration 0.2 μg/mL after primary vaccination. Postprimary and postbooster, percentages of subjects with antibody concentration 0.2 μg/mL or opsonophagocytic activity titer 8 were generally consistent between groups for each pneumococcal serotype common to both vaccines. The safety and reactogenicity profiles of PHiD-CV and 7vCRM were generally comparable after both primary and booster vaccination. Conclusions: In this Korean study, 3-dose PHiD-CV priming followed by a booster dose was immunogenic for all 10 vaccine pneumococcal serotypes and protein D. Noninferiority to 7vCRM in terms of enzyme-linked immunosorbent assay threshold responses postpriming was demonstrated. The safety and reactogenicity profiles of both vaccines when coadministered with Hib vaccine were generally comparable. © 2011 by Lippincott Williams & Wilkins.-
dc.languageEnglish-
dc.titleResponse to primary and booster vaccination with 10-valent pneumococcal nontypeable haemophilus influenzae protein D conjugate vaccine in Korean infants-
dc.typeArticle-
dc.relation.issue12-
dc.relation.volume30-
dc.relation.indexSCI-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpagee235-
dc.relation.lastpagee243-
dc.relation.journaltitlePediatric Infectious Disease Journal-
dc.identifier.doi10.1097/INF.0b013e31822a8541-
dc.identifier.wosidWOS:000297406100002-
dc.identifier.scopusid2-s2.0-81855221739-
dc.author.googleKim C.-H.-
dc.author.googleKim J.S.-
dc.author.googleCha S.-H.-
dc.author.googleKim K.-N.-
dc.author.googleKim J.-D.-
dc.author.googleLee K.Y.-
dc.author.googleKim H.M.-
dc.author.googleKim J.-H.-
dc.author.googleHyuk S.-
dc.author.googleHong J.-Y.-
dc.author.googlePark S.E.-
dc.author.googleKim Y.-K.-
dc.author.googleKim N.H.-
dc.author.googleFanic A.-
dc.author.googleBorys D.-
dc.author.googleRuiz-Guinazu J.-
dc.author.googleMoreira M.-
dc.author.googleSchuerman L.-
dc.author.googleKim K.-H.-
dc.contributor.scopusid김경효(35448653000)-
dc.date.modifydate20180329110334-
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의과대학 > 의학과 > Journal papers
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