Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 김경효 | * |
dc.date.accessioned | 2016-08-28T12:08:33Z | - |
dc.date.available | 2016-08-28T12:08:33Z | - |
dc.date.issued | 2011 | * |
dc.identifier.issn | 0891-3668 | * |
dc.identifier.other | OAK-8192 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/222127 | - |
dc.description.abstract | Background: This randomized single-blind study in Korea evaluated noninferiority of the 10-valent pneumococcal nontypeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) versus the 7-valent pneumococcal conjugate vaccine (7vCRM) when both were coadministered with H. influenzae type b (Hib) conjugate vaccine, as opposed to coadministration with diphtheria-tetanus- acellular pertussis-based combination vaccines in previous studies. Methods: Infants received 3 primary doses at 2, 4, and 6 months and a booster dose at 12 to 18 months of PHiD-CV (N = 374) or 7vCRM (N = 129), both coadministered with Hib vaccine. Immune responses were measured 1 month postdose 3 and postbooster using 22F-inhibition enzyme-linked immunosorbent assay and functional opsonophagocytic activity assay. Results: PHiD-CV-induced antibody responses against each of the vaccine pneumococcal serotypes and protein D. Noninferiority to 7vCRM was demonstrated for all 10 PHiD-CV serotypes in terms of percentages of subjects reaching an antibody concentration 0.2 μg/mL after primary vaccination. Postprimary and postbooster, percentages of subjects with antibody concentration 0.2 μg/mL or opsonophagocytic activity titer 8 were generally consistent between groups for each pneumococcal serotype common to both vaccines. The safety and reactogenicity profiles of PHiD-CV and 7vCRM were generally comparable after both primary and booster vaccination. Conclusions: In this Korean study, 3-dose PHiD-CV priming followed by a booster dose was immunogenic for all 10 vaccine pneumococcal serotypes and protein D. Noninferiority to 7vCRM in terms of enzyme-linked immunosorbent assay threshold responses postpriming was demonstrated. The safety and reactogenicity profiles of both vaccines when coadministered with Hib vaccine were generally comparable. © 2011 by Lippincott Williams & Wilkins. | * |
dc.language | English | * |
dc.title | Response to primary and booster vaccination with 10-valent pneumococcal nontypeable haemophilus influenzae protein D conjugate vaccine in Korean infants | * |
dc.type | Article | * |
dc.relation.issue | 12 | * |
dc.relation.volume | 30 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | e235 | * |
dc.relation.lastpage | e243 | * |
dc.relation.journaltitle | Pediatric Infectious Disease Journal | * |
dc.identifier.doi | 10.1097/INF.0b013e31822a8541 | * |
dc.identifier.wosid | WOS:000297406100002 | * |
dc.identifier.scopusid | 2-s2.0-81855221739 | * |
dc.author.google | Kim C.-H. | * |
dc.author.google | Kim J.S. | * |
dc.author.google | Cha S.-H. | * |
dc.author.google | Kim K.-N. | * |
dc.author.google | Kim J.-D. | * |
dc.author.google | Lee K.Y. | * |
dc.author.google | Kim H.M. | * |
dc.author.google | Kim J.-H. | * |
dc.author.google | Hyuk S. | * |
dc.author.google | Hong J.-Y. | * |
dc.author.google | Park S.E. | * |
dc.author.google | Kim Y.-K. | * |
dc.author.google | Kim N.H. | * |
dc.author.google | Fanic A. | * |
dc.author.google | Borys D. | * |
dc.author.google | Ruiz-Guinazu J. | * |
dc.author.google | Moreira M. | * |
dc.author.google | Schuerman L. | * |
dc.author.google | Kim K.-H. | * |
dc.contributor.scopusid | 김경효(35448653000) | * |
dc.date.modifydate | 20240301081003 | * |