Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 박혜영 | - |
dc.date.accessioned | 2016-08-28T12:08:32Z | - |
dc.date.available | 2016-08-28T12:08:32Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0007-0963 | - |
dc.identifier.other | OAK-8169 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/222111 | - |
dc.description.abstract | Background Serotonin (5-hydroxytryptamine, 5-HT) levels are increased by light exposure but the role and mechanism of 5-HT in the pigmentation of skin cells are unclear. Objectives To clarify the effect of 5-HT on melanogenesis and to determine the 5-HT receptor subtype involved. Methods B16F10, SK-MEL-2 and Melan-A cells were cultured in Dulbecco's modified Eagle's medium with low fetal bovine serum. The three cell lines were treated with various concentrations of 5-HT, and 5-HT receptor agonists and antagonists. The involvement of the 5-HT receptor 2A (5-HTR2A) was examined by gene silencing and use of 5-HTR2A antagonists. Results 5-HT and the 5-HTR2A agonist, DOI, increased melanogenesis in the three cell lines. These increased events were suppressed by 5-HTR2A antagonists or gene silencing of the HTR2A gene. Conclusions 5-HTR2A is involved in melanogenesis. These findings highlight the role of 5-HT and suggest new ways of controlling melanogenesis. © 2011 British Association of Dermatologists 2011. | - |
dc.language | English | - |
dc.title | Serotonin induces melanogenesis via serotonin receptor 2A | - |
dc.type | Article | - |
dc.relation.issue | 6 | - |
dc.relation.volume | 165 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 1344 | - |
dc.relation.lastpage | 1348 | - |
dc.relation.journaltitle | British Journal of Dermatology | - |
dc.identifier.doi | 10.1111/j.1365-2133.2011.10490.x | - |
dc.identifier.wosid | WOS:000297320000127 | - |
dc.identifier.scopusid | 2-s2.0-82255192406 | - |
dc.author.google | Lee H.J. | - |
dc.author.google | Park M.K. | - |
dc.author.google | Kim S.Y. | - |
dc.author.google | Park Choo H.Y. | - |
dc.author.google | Lee A.Y. | - |
dc.author.google | Lee C.H. | - |
dc.contributor.scopusid | 박혜영(34972649500;57200273796) | - |
dc.date.modifydate | 20230411110509 | - |