Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이서구 | * |
dc.date.accessioned | 2016-08-28T12:08:29Z | - |
dc.date.available | 2016-08-28T12:08:29Z | - |
dc.date.issued | 2011 | * |
dc.identifier.issn | 0304-3835 | * |
dc.identifier.other | OAK-8146 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/222091 | - |
dc.description.abstract | Previously, we reported that a novel secretory protein, pancreatic adenocarcinoma up-regulated factor (PAUF), which is highly expressed in pancreatic cancer and mediates the growth and metastasis of pancreatic cancer cells. In this study, we generated and characterized a 2'-fluoropyrimidine modified RNA aptamer (P12FR2) directed against human PAUF. P12FR2 binds specifically to human PAUF with an estimated apparent K D of 77. nM. P12FR2 aptamer inhibits PAUF-induced migration of PANC-1, human pancreatic cancer cells, in a wound healing assay. Moreover, intraperitoneal injection of P12FR2 decreased tumor growth by about 60% in an in vivo xenograft model with CFPAC-1 pancreatic cancer cells, without causing a loss of weight in the treated mice. Taken together, we propose here that PAUF-specific RNA aptamer, P12FR2, has the potential to be effective in the therapy of human pancreatic cancer. © 2011 Elsevier Ireland Ltd. | * |
dc.language | English | * |
dc.title | An RNA aptamer that specifically binds pancreatic adenocarcinoma up-regulated factor inhibits migration and growth of pancreatic cancer cells | * |
dc.type | Article | * |
dc.relation.issue | 1 | * |
dc.relation.volume | 313 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 76 | * |
dc.relation.lastpage | 83 | * |
dc.relation.journaltitle | Cancer Letters | * |
dc.identifier.doi | 10.1016/j.canlet.2011.08.027 | * |
dc.identifier.wosid | WOS:000297086500008 | * |
dc.identifier.scopusid | 2-s2.0-80054097776 | * |
dc.author.google | Kim Y.-H. | * |
dc.author.google | Sung H.J. | * |
dc.author.google | Kim S. | * |
dc.author.google | Kim E.-O. | * |
dc.author.google | Lee J.W. | * |
dc.author.google | Moon J.Y. | * |
dc.author.google | Choi K. | * |
dc.author.google | Jung J.-E. | * |
dc.author.google | Lee Y. | * |
dc.author.google | Koh S.S. | * |
dc.author.google | Rhee S.G. | * |
dc.author.google | Heo K. | * |
dc.author.google | Kim I.-H. | * |
dc.contributor.scopusid | 이서구(7401852092) | * |
dc.date.modifydate | 20240423081003 | * |