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Uric Acid and Chronic Kidney Disease: New Understanding of an Old Problem

Title
Uric Acid and Chronic Kidney Disease: New Understanding of an Old Problem
Authors
Kang D.-H.Chen W.
Ewha Authors
강덕희
SCOPUS Author ID
강덕희scopus
Issue Date
2011
Journal Title
Seminars in Nephrology
ISSN
0270-9295JCR Link
Citation
vol. 31, no. 5, pp. 447 - 452
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Although an elevation of serum uric acid level is often associated with chronic kidney disease (CKD), it remains controversial whether hyperuricemia per se is a true risk factor for the development or aggravation of CKD. Recent epidemiologic studies in healthy populations or in subjects with established kidney disease have reported the independent role of uric acid in lowering glomerular filtration rate and increasing the risk for new-onset kidney disease. Furthermore, lowering uric acid in patients with established renal disease has been reported to stabilize renal function independent of other confounders, suggesting a causative role of elevated uric acid in progression of CKD, rather than as an incidental finding related to CKD severity. In this manuscript we will discuss the potential role of uric acid in the development and aggravation of CKD based on epidemiologic, clinical and experimental studies. Given the worldwide epidemic of CKD, the importance of identifying modifiable risk factors of CKD, and the clinical implication of hyperuricemia in CKD, we propose large randomized clinical trials to investigate whether uric acid-lowering therapy can slow the progression of CKD. © 2011 Elsevier Inc.
DOI
10.1016/j.semnephrol.2011.08.009
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의학전문대학원 > 의학과 > Journal papers
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