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Two-day fasting prior to intestinal ischemia-reperfusion injury on bacterial translocation in rats

Title
Two-day fasting prior to intestinal ischemia-reperfusion injury on bacterial translocation in rats
Authors
Park J.J.Chung K.-Y.Nam Y.S.
Ewha Authors
정구용
SCOPUS Author ID
정구용scopus
Issue Date
2011
Journal Title
Journal of Investigative Surgery
ISSN
0894-1939JCR Link
Citation
vol. 24, no. 6, pp. 262 - 266
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Purpose: The aim of this study is to verify the effect of two-day fasting prior to intestinal ischemia-reperfusion (I/R) injury on bacterial translocation (BT). Materials and Methods: Mail SpragueDawley rats were divided into four groups: group 1, control rats that underwent sham operation only; group 2, rats fasted for two days prior to sham operation; group 3, rats that underwent occlusion of mesenteric vessels for 30 min followed by reperfusion for 4 hr; and group 4, rats fasted for two days prior to the same intestinal I/R injury as in group 3. In all groups, E. coli labeled with 99mTc were inoculated into the terminal ileum. Two hr after inoculation of E. coli, the rats were killed. A segment of ileum was obtained for histological examination and samples of mesenteric lymph nodes (MLNs), liver, lung, blood, and spleen were obtained for radioactivity determination. Results: There were no significant differences in the intestinal mucosa and radioactivity of all samples between groups 1 and 2. Group 3 showed significantly shorter mucosa and villi, and higher radioactivity of samples, except for MLNs, compared to group 1. Group 4 showed similar mucosa and villi, but significantly higher radioactivity of samples, except for MLNs, compared to group 3. Conclusion: Two-day fasting without I/R injury does not cause mucosal change and BT, but in cases following intestinal I/R injury, two-day fasting increases the susceptibility of BT to systemic organs in rats. © 2011 Informa Healthcare USA, Inc.
DOI
10.3109/08941939.2011.589886
Appears in Collections:
의과대학 > 의학과 > Journal papers
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