Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 서은경 | * |
dc.contributor.author | 한아름 | * |
dc.contributor.author | 이윤실 | * |
dc.date.accessioned | 2016-08-28T12:08:23Z | - |
dc.date.available | 2016-08-28T12:08:23Z | - |
dc.date.issued | 2011 | * |
dc.identifier.issn | 0163-3864 | * |
dc.identifier.other | OAK-8073 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/222033 | - |
dc.description.abstract | Seven new diarylheptanoids, (-)-(R)-4′-hydroxyyashabushiketol (1), (3S,5S)-alpinikatin (2), katsumain C (3), 7-epi-katsumain C (4), ent-alpinnanin B (5), ent-alpinnanin A (6), and ent-calyxin H (8), were isolated from the EtOAc extract of the seeds of Alpinia katsumadai together with three known compounds, alpinnanin B (7), epicalyxin H (9), and calyxin H (10). Each isomer mixture of 3 and 4, 5-7, and 8-10 was separated successfully by preparative HPLC using a chiral column. The three isomer mixtures (3 and 4, 5-7, 8-10) at 1 μM increased expression of heat shock factor 1 (HSF1) with fold increases of 1.438, 1.190, and 1.316, respectively, which was accompanied with increased expression of heat shock protein (HSP) 27 (1.403-, 1.250-, and 1.270-fold, respectively) and HSP70 (1.373-, 1.313-, and 1.229-fold, respectively) without cellular cytotoxicity, suggesting a possible application of these compounds as HSP inducers. Celastrol was used as a positive control of HSP induction, producing fold increases of 1.066 (HSF1), 1.216 (HSP27), and 1.371 (HSP70) at 1 μM. Compounds 1 and 2 did not affect the induction of HSF1 protein. © 2011 The American Chemical Society and American Society of Pharmacognosy. | * |
dc.language | English | * |
dc.title | Diarylheptanoids from the seeds of Alpinia katsumadai as heat shock factor 1 inducers | * |
dc.type | Article | * |
dc.relation.issue | 10 | * |
dc.relation.volume | 74 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 2109 | * |
dc.relation.lastpage | 2115 | * |
dc.relation.journaltitle | Journal of Natural Products | * |
dc.identifier.doi | 10.1021/np200355n | * |
dc.identifier.wosid | WOS:000296206500011 | * |
dc.identifier.scopusid | 2-s2.0-80055069388 | * |
dc.author.google | Nam J.-W. | * |
dc.author.google | Kang G.-Y. | * |
dc.author.google | Han A.-R. | * |
dc.author.google | Lee D. | * |
dc.author.google | Lee Y.-S. | * |
dc.author.google | Seo E.-K. | * |
dc.contributor.scopusid | 서은경(7005953758) | * |
dc.contributor.scopusid | 한아름(56278315000;34769874800) | * |
dc.contributor.scopusid | 이윤실(17137192000) | * |
dc.date.modifydate | 20240130112016 | * |