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No correlation between COMT genotype and entacapone benefits in Parkinson's disease
- No correlation between COMT genotype and entacapone benefits in Parkinson's disease
- Kim J.S.; Kim J.-Y.; Kim J.-M.; Kim J.W.; Chung S.J.; Kim S.R.; Kim M.J.; Kim H.-T.; Choi K.-G.; Shin D.-I.; Sung Y.H.; Lee K.-S.; Kim H.-J.; Cho J.; Park M.Y.; Park H.-Y.; Choi S.-M.; Park K.-W.; Lee H.-W.; Ahn T.-B.; Kwon O.D.; Kim S.-J.; Jeon B.S.
- Ewha Authors
- SCOPUS Author ID
- Issue Date
- Journal Title
- Neurology Asia
- vol. 16, no. 3, pp. 211 - 216
- SCIE; SCOPUS
- Catechol-O-methyltransferase (COMT) inhibitors are used to increase the bioavailability of therapeutic L-dopa. We examined the efficacy of entacapone in Parkinson's disease patients who had daily "off" duration of ≤2 hours, and carried different COMT polymorphisms. A total of 168 PD patients were recruited from 19 centers. Subjects were administered with 100-200 mg of entacapone in combination with each dose of L-dopa for 2 months. The clinical efficacy was evaluated based on the activities of daily living (ADL), score on the Unified Parkinson's Disease Rating Scale (UPDRS), Hoehn and Yahr (H&Y) stage, and Clinical Global Impression (CGI). COMT polymorphisms were genotyped. 3-O-methyldopa (3-OMD) levels were measured before and after the administration of entacapone. Entacapone administration produced significant improvements in the total daily "on" duration, ADL, UPDRS score, and H&Y stage. Nineteen patients (11.3%) had the low-activity COMT genotype, 68 patients (40.5%) had the intermediate-activity COMT genotype, and 81patients (48.2%) had the high-activity COMT genotype. The efficacy, and adverse effects of entacapone therapy did not differ between the three groups. There was a significant reduction in 3-OMD, but this did not differ among the three genotypes. Entacapone provided an increased "on" duration and improved motor function in all COMT genotypes.
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