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No correlation between COMT genotype and entacapone benefits in Parkinson's disease

Title
No correlation between COMT genotype and entacapone benefits in Parkinson's disease
Authors
Kim J.S.Kim J.-Y.Kim J.-M.Kim J.W.Chung S.J.Kim S.R.Kim M.J.Kim H.-T.Choi K.-G.Shin D.-I.Sung Y.H.Lee K.-S.Kim H.-J.Cho J.Park M.Y.Park H.-Y.Choi S.-M.Park K.-W.Lee H.-W.Ahn T.-B.Kwon O.D.Kim S.-J.Jeon B.S.
Ewha Authors
최경규
SCOPUS Author ID
최경규scopus
Issue Date
2011
Journal Title
Neurology Asia
ISSN
1823-6138JCR Link
Citation
vol. 16, no. 3, pp. 211 - 216
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Catechol-O-methyltransferase (COMT) inhibitors are used to increase the bioavailability of therapeutic L-dopa. We examined the efficacy of entacapone in Parkinson's disease patients who had daily "off" duration of ≤2 hours, and carried different COMT polymorphisms. A total of 168 PD patients were recruited from 19 centers. Subjects were administered with 100-200 mg of entacapone in combination with each dose of L-dopa for 2 months. The clinical efficacy was evaluated based on the activities of daily living (ADL), score on the Unified Parkinson's Disease Rating Scale (UPDRS), Hoehn and Yahr (H&Y) stage, and Clinical Global Impression (CGI). COMT polymorphisms were genotyped. 3-O-methyldopa (3-OMD) levels were measured before and after the administration of entacapone. Entacapone administration produced significant improvements in the total daily "on" duration, ADL, UPDRS score, and H&Y stage. Nineteen patients (11.3%) had the low-activity COMT genotype, 68 patients (40.5%) had the intermediate-activity COMT genotype, and 81patients (48.2%) had the high-activity COMT genotype. The efficacy, and adverse effects of entacapone therapy did not differ between the three groups. There was a significant reduction in 3-OMD, but this did not differ among the three genotypes. Entacapone provided an increased "on" duration and improved motor function in all COMT genotypes.
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의학전문대학원 > 의학과 > Journal papers
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