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Large-scale genome-wide association studies in east Asians identify new genetic loci influencing metabolic traits

Title
Large-scale genome-wide association studies in east Asians identify new genetic loci influencing metabolic traits
Authors
Kim Y.J.Go M.J.Hu C.Hong C.B.Kim Y.K.Lee J.Y.Hwang J.-Y.Oh J.H.Kim D.-J.Kim N.H.Kim S.Hong E.J.Kim J.-H.Min H.Kim Y.Zhang R.Jia W.Okada Y.Takahashi A.Kubo M.Tanaka T.Kamatani N.Matsuda K.Park T.Oh B.Kimm K.Kang D.Shin C.Cho N.H.Kim H.-L.Han B.-G.Lee J.-Y.Cho Y.S.
Ewha Authors
김형래
SCOPUS Author ID
김형래scopus
Issue Date
2011
Journal Title
Nature Genetics
ISSN
1061-4036JCR Link
Citation
vol. 43, no. 10, pp. 990 - 997
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
To identify the genetic bases for nine metabolic traits, we conducted a meta-analysis combining Korean genome-wide association results from the KARE project (n = 8,842) and the HEXA shared control study (n = 3,703). We verified the associations of the loci selected from the discovery meta-analysis in the replication stage (30,395 individuals from the BioBank Japan genome-wide association study and individuals comprising the Health2 and Shanghai Jiao Tong University Diabetes cohorts). We identified ten genome-wide significant signals newly associated with traits from an overall meta-analysis. The most compelling associations involved 12q24.11 (near MYL2) and 12q24.13 (in C12orf51) for high-density lipoprotein cholesterol, 2p21 (near SIX2-SIX3) for fasting plasma glucose, 19q13.33 (in RPS11) and 6q22.33 (in RSPO3) for renal traits, and 12q24.11 (near MYL2), 12q24.13 (in C12orf51 and near OAS1), 4q31.22 (in ZNF827) and 7q11.23 (near TBL2-BCL7B) for hepatic traits. These findings highlight previously unknown biological pathways for metabolic traits investigated in this study. © 2011 Nature America, Inc. All rights reserved.
DOI
10.1038/ng.939
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의학전문대학원 > 의학과 > Journal papers
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