Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 신윤용 | * |
dc.contributor.author | 김대기 | * |
dc.date.accessioned | 2016-08-28T12:08:17Z | - |
dc.date.available | 2016-08-28T12:08:17Z | - |
dc.date.issued | 2011 | * |
dc.identifier.issn | 0223-5234 | * |
dc.identifier.other | OAK-8003 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/221974 | - |
dc.description.abstract | A series of 1-substituted-3(5)-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl) pyrazoles 14a-d, 15a-d, 17a, 17b, 18a-d, 19a, and 19b has been synthesized and evaluated for their ALK5 inhibitory activity in an enzyme assay and in a cell-based luciferase reporter assay. The 2-[3-(6-methylpyridin-2-yl)-4- (quinoxalin-6-yl)-1H-pyrazol-1-yl]-N-phenylethanethioamide (18a) inhibited ALK5 phosphorylation with an IC 50 value of 0.013 μM and showed 80% inhibition at 0.1 μM in a luciferase reporter assay using HaCaT cells permanently transfected with p3TP-luc reporter construct. © 2011 Elsevier Masson SAS. All rights reserved. | * |
dc.language | English | * |
dc.title | Synthesis and biological evaluation of 1-substituted-3(5)-(6-methylpyridin- 2-yl)-4-(quinoxalin-6-yl)pyrazoles as transforming growth factor-β type 1 receptor kinase inhibitors | * |
dc.type | Article | * |
dc.relation.issue | 9 | * |
dc.relation.volume | 46 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 3917 | * |
dc.relation.lastpage | 3925 | * |
dc.relation.journaltitle | European Journal of Medicinal Chemistry | * |
dc.identifier.doi | 10.1016/j.ejmech.2011.05.063 | * |
dc.identifier.wosid | WOS:000295237400040 | * |
dc.identifier.scopusid | 2-s2.0-80052951712 | * |
dc.author.google | Jin C.H. | * |
dc.author.google | Sreenu D. | * |
dc.author.google | Krishnaiah M. | * |
dc.author.google | Subrahmanyam V.B. | * |
dc.author.google | Rao K.S. | * |
dc.author.google | Nagendra Mohan A.V. | * |
dc.author.google | Park C.-Y. | * |
dc.author.google | Son J.-Y. | * |
dc.author.google | Son D.-H. | * |
dc.author.google | Park H.-J. | * |
dc.author.google | Sheen Y.Y. | * |
dc.author.google | Kim D.-K. | * |
dc.contributor.scopusid | 신윤용(6603872711) | * |
dc.contributor.scopusid | 김대기(35083694200) | * |
dc.date.modifydate | 20240118164500 | * |