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Three cases showing false results in the detection of monoclonal components using capillary electrophoresis

Title
Three cases showing false results in the detection of monoclonal components using capillary electrophoresis
Authors
Cho S.Y.Kim Y.Lee A.Park T.S.Lee H.J.Suh J.-T.
Ewha Authors
이안복
Issue Date
2011
Journal Title
Laboratory Medicine
ISSN
0007-5027JCR Link
Citation
vol. 42, no. 10, pp. 602 - 606
Indexed
SCIE; SCOPUS WOS scopus
Abstract
In the detection of monoclonal proteins using capillary electrophoresis (CE), several problems have been described, especially for small amounts of paraprotein, light chain (LC) disease, and cases associated with contrast interference. In this report, we describe 3 unusual cases that showed false-positive peaks due to radiologic contrast interference and the escape of monoclonal LC in CE. In these cases questionable for monoclonal components, conventional gel tests and free LC assays could be helpful to confirm monoclonal gammopathy. Therefore, multiple methodological modalities should be combined for diagnosing and monitoring plasma cell neoplasms and related disorders.
DOI
10.1309/LMHZLIMXVYLWT7SQ
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의료원 > 의료원 > Journal papers
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