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Non-dipper status and left ventricular hypertrophy as predictors of incident chronic kidney disease
- Non-dipper status and left ventricular hypertrophy as predictors of incident chronic kidney disease
- An H.R.; Park S.; Yoo T.-H.; Kang S.-W.; Ryu J.-H.; Lee Y.K.; Yu M.; Ryu D.-R.; Kim S.J.; Kang D.-H.; Choi K.B.
- Ewha Authors
- 강덕희; 최규복; 김승정; 류동열
- SCOPUS Author ID
- 강덕희; 최규복; 김승정; 류동열
- Issue Date
- Journal Title
- Journal of Korean Medical Science
- Journal of Korean Medical Science vol. 26, no. 9, pp. 1185 - 1190
- SCI; SCIE; SCOPUS; KCI
- Document Type
- We have hypothesized that non-dipper status and left ventricular hypertrophy (LVH) are associated with the development of chronic kidney disease (CKD) in non-diabetic hypertensive patients. This study included 102 patients with an estimated glomerular filtration rate (eGFR) ≥ 60 mL/min/1.73 m2. Ambulatory blood pressure monitoring and echocardiography were performed at the beginning of the study, and the serum creatinine levels were followed. During the average follow-up period of 51 months, CKD developed in 11 patients. There was a significant difference in the incidence of CKD between dippers and non-dippers (5.0% vs 19.0%, P < 0.05). Compared to patients without CKD, patients with incident CKD had a higher urine albumin/creatinine ratio (52.3 ± 58.6 mg/g vs 17.8 ± 29.3 mg/g, P < 0.01), non-dipper status (72.7% vs 37.4%, P < 0.05), the presence of LVH (27.3% vs 5.5%, P < 0.05), and a lower serum HDL-cholesterol level (41.7 ± 8.3 mg/dL vs 50.4 ± 12.4 mg/dL, P < 0.05). Based on multivariate Cox regression analysis, non-dipper status and the presence of LVH were independent predictors of incident CKD. These findings suggest that non-dipper status and LVH may be the therapeutic targets for preventing the development of CKD in non-diabetic hypertensive patients. © 2011 The Korean Academy of Medical Sciences.
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