Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이서구 | * |
dc.contributor.author | 강상원 | * |
dc.contributor.author | 오구택 | * |
dc.contributor.author | 이미니 | * |
dc.date.accessioned | 2016-08-28T12:08:15Z | - |
dc.date.available | 2016-08-28T12:08:15Z | - |
dc.date.issued | 2011 | * |
dc.identifier.issn | 0009-7330 | * |
dc.identifier.other | OAK-7977 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/221954 | - |
dc.description.abstract | Rationale: Peroxiredoxin 2 (Prdx2), a thiol-specific peroxidase, has been reported to regulate proinflammatory responses, vascular remodeling, and global oxidative stress. Objective: Although Prdx2 has been proposed to retard atherosclerosis development, no direct evidence and mechanisms have been reported. Methods and Results: We show that Prdx2 is highly expressed in endothelial and immune cells in atherosclerotic lesions and blocked the increase of endogenous H2O2 by atherogenic stimulation. Deficiency of Prdx2 in apolipoprotein E-deficient (ApoE-/-) mice accelerated plaque formation with enhanced activation of p65, c-Jun, JNKs, and p38 mitogen-activated protein kinase; and these proatherogenic effects of Prdx2 deficiency were rescued by administration of the antioxidant ebselen. In bone marrow transplantation experiments, we found that Prdx2 has a major role in inhibiting atherogenic responses in both vascular and immune cells. Prdx2 deficiency resulted in increased expression of vascular adhesion molecule-1, intercellular adhesion molecule-1, and monocyte chemotactic protein-1, which led to increased immune cell adhesion and infiltration into the aortic intima. Compared with deficiency of glutathione peroxidase 1 or catalase, Prdx2 deficiency showed a severe predisposition to develop atherosclerosis. Conclusions: Prdx2 is a specific peroxidase that inhibits atherogenic responses in vascular and inflammatory cells, and specific activation of Prdx2 may be an effective means of antiatherogenic therapy. © 2011 American Heart Association, Inc. | * |
dc.language | English | * |
dc.title | Peroxiredoxin 2 deficiency exacerbates atherosclerosis in apolipoprotein E-deficient mice | * |
dc.type | Article | * |
dc.relation.issue | 7 | * |
dc.relation.volume | 109 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 739 | * |
dc.relation.lastpage | 749 | * |
dc.relation.journaltitle | Circulation Research | * |
dc.identifier.doi | 10.1161/CIRCRESAHA.111.245530 | * |
dc.identifier.wosid | WOS:000294950000006 | * |
dc.identifier.scopusid | 2-s2.0-80052970775 | * |
dc.author.google | Park J.-G. | * |
dc.author.google | Yoo J.-Y. | * |
dc.author.google | Jeong S.-J. | * |
dc.author.google | Choi J.-H. | * |
dc.author.google | Lee M.-R. | * |
dc.author.google | Lee M.-N. | * |
dc.author.google | Hwa Lee J. | * |
dc.author.google | Kim H.C. | * |
dc.author.google | Jo H. | * |
dc.author.google | Yu D.-Y. | * |
dc.author.google | Kang S.W. | * |
dc.author.google | Rhee S.G. | * |
dc.author.google | Lee M.-H. | * |
dc.author.google | Oh G.T. | * |
dc.contributor.scopusid | 이서구(7401852092) | * |
dc.contributor.scopusid | 강상원(55731433900) | * |
dc.contributor.scopusid | 오구택(7007056663) | * |
dc.contributor.scopusid | 이미니(35285954900;56136972000) | * |
dc.date.modifydate | 20240423081003 | * |