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Protective effects of 1,3-diaryl-2-propen-1-one derivatives against H 2O 2-induced damage in SK-N-MC cells

Title
Protective effects of 1,3-diaryl-2-propen-1-one derivatives against H 2O 2-induced damage in SK-N-MC cells
Authors
Bayati S.Yazdanparast R.Majd S.S.Oh S.
Ewha Authors
오세관
SCOPUS Author ID
오세관scopus
Issue Date
2011
Journal Title
Journal of Applied Toxicology
ISSN
0260-437XJCR Link
Citation
vol. 31, no. 6, pp. 545 - 553
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Alzheimer's disease (AD) is an age-related neurodegenerative disorder of the central nervous system resulting in memory loss and dementia. Some of the associated pathogenic changes are amyloid peptide aggregation, excitotoxicity, oxidative stress and inflammation. Oxidative stress plays an indispensable role in the pathophysiology of AD. Therefore, antioxidant therapies appear to be promising approaches in dealing with AD patients. In that line, we evaluated the free radical scavenging capabilities of 13 different chalcones (1,3-diphenyl-2-propen-1-one) derivatives against the free-radical damaging effects of hydrogen peroxide (H 2O 2) on the SK-N-MC neuroblastoma cell line. Pretreatment of the cells for 3h with 20μ m of each of these derivatives (compounds 8-20) followed by exposure to 300μ m H 2O 2 for 24h indicated that all compounds, except compound 20, were capable of restoring the viabilities of cells relative to the control (H 2O 2-treated) cells. The destructive effect of H 2O 2 on the adhesive behavior of the cells was almost totally restored by each of the derivatives. In addition, each of the derivatives except compounds 20 and 14 significantly reduced the extent of lipofuscin formation among the cells time-dependently. Despite these activities, some of the derivatives, such as compounds 12 and 19, did not reduce the H 2O 2-induced intracellular ROS (reactive oxygen species) levels, meaning that these two derivatives act through a different mechanism other than free-radical scavenging activity. On the other hand, for those derivatives acting as anti-oxidants, structure-activity evaluation clearly revealed that the hydroxyl group of vanillin ring is required for their free-radical scavenging activities. © 2010 John Wiley & Sons, Ltd.
DOI
10.1002/jat.1594
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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