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dc.contributor.author김대기-
dc.date.accessioned2017-08-28T22:05:39Z-
dc.date.available2017-08-28T22:05:39Z-
dc.date.issued2011-
dc.identifier.issn1051-0443-
dc.identifier.otherOAK-7948-
dc.identifier.urihttp://dspace.ewha.ac.kr/handle/2015.oak/221936-
dc.description.abstractPurpose: To evaluate the efficacy of an activin receptorlike kinase (ALK) 5 inhibitor, IN-1233, for the prevention of neointimal hyperplasia after bare stent placement in a rat common iliac artery (CIA) model. Materials and Methods: All experiments were approved by the committee of animal research. A self-expanding metallic bare stent (2 mm × 6 mm) was inserted into the left CIA of 26 Sprague-Dawley male rats (300360 g) under fluoroscopic guidance. IN-1233 was injected via the intraperitoneal route daily in 13 rats for 8 weeks after stent placement (group A); the other 13 rats underwent stent placement only (group B). Angiography was performed immediately and 4 weeks and 8 weeks after stent placement. Rats were sacrificed at 8 weeks after stent placement, and histologic findings were obtained. The neointimal area (NA), percentage of neointimal hyperplasia (%NH), and neointimal-to-medial area ratio (N/M) were assessed and compared between the two groups. Results: Stent placement was technically successful. In 25 rats, arteries with stent placement were angiographically patent, whereas 1 rat in group B had an occlusion. The NA (0.31 mm 2 ± 0.09 vs 0.56 mm 2 ± 0.17; P <.001), the %NH (26.16% ± 8.75 vs 44.71% ± 17.75; P <.001) and the N/M (1.93 ± 0.77 vs 4.77 ± 2.26; P <.001) were significantly decreased in group A compared with group B. Conclusions: IN-1233 was shown in this study to be effective for the prevention of neointimal hyperplasia after bare metallic stent placement in a rat CIA model. © 2011 SIR.-
dc.languageEnglish-
dc.titleRole of IN-1233 in the prevention of neointimal hyperplasia after stent placement in a rat artery model-
dc.typeArticle-
dc.relation.issue9-
dc.relation.volume22-
dc.relation.indexSCI-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage1321-
dc.relation.lastpage1328-
dc.relation.journaltitleJournal of Vascular and Interventional Radiology-
dc.identifier.doi10.1016/j.jvir.2011.02.015-
dc.identifier.wosidWOS:000294592600016-
dc.identifier.scopusid2-s2.0-80052028209-
dc.author.googleYoon H.-J.-
dc.author.googleSong H.-Y.-
dc.author.googleKim J.H.-
dc.author.googleHong K.-S.-
dc.author.googleKim Y.J.-
dc.author.googlePark H.G.-
dc.author.googleKim D.-K.-
dc.contributor.scopusid김대기(35083694200)-
dc.date.modifydate20170518153159-
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약학대학 > 약학과 > Journal papers
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