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The immunohistochemical patterns of calcification-related molecules in the epidermis and dermis of the zebrafish (Danio rerio)

Title
The immunohistochemical patterns of calcification-related molecules in the epidermis and dermis of the zebrafish (Danio rerio)
Authors
Hong Y.J.Choi Y.W.Myung K.B.Choi H.Y.
Ewha Authors
명기범최혜영최유원
SCOPUS Author ID
명기범scopusscopus; 최혜영scopus; 최유원scopus
Issue Date
2011
Journal Title
Annals of Dermatology
ISSN
1013-9087JCR Link
Citation
vol. 23, no. 3, pp. 299 - 303
Indexed
SCIE; SCOPUS; KCI WOS scopus
Abstract
Background: The scales of bony fish represent a significant reservoir of calcium and calcification of the elasmoid scale is known to be associated with deposition of mineral crystals from the epidermis to dermis. However, little is known about the exact mechanisms of calcium deposition, mobilization and regeneration occurring in the zebrafish skin. Objective: The purpose of this study was to investigate the expression of calcification-related molecular mediators in both the epidermis and dermis of the zebrafish (Danio rerio), using immunohistochemical study. Methods: We examined the skin of zebrafish in four populations of different ages (i.e. 20 days post-fertilization (dpf), 35 dpf, 50 dpf, and the adult zebrafish), using several immunohistochemical markers, including bone morphogenetic protein 4 (BMP-4), β-catenin, osteocalcin, osteopontin and osteonectin. Results: BMP-4, osteopontin and osteonectin were moderately expressed in the epidermis of zebrafish after 35 dpf. Also, some of the cells in the upper dermis showed strong positivity for BMP-4, osteocalcin, osteopontin and osteonetin. Conclusion: Our results suggest that BMP-4, osteocalcin, osteopontin and osteonectin may play a role in the process of calcification of the elasmoid scale.
DOI
10.5021/ad.2011.23.3.299
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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