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Lipid-Soluble Ginseng Extract Induces Apoptosis and G0/G1 Cell Cycle Arrest in NCI-H460 Human Lung Cancer Cells
- Title
- Lipid-Soluble Ginseng Extract Induces Apoptosis and G0/G1 Cell Cycle Arrest in NCI-H460 Human Lung Cancer Cells
- Authors
- Kang M.R.; Kim H.M.; Kang J.S.; Lee K.; Lee S.D.; Hyun D.-H.; In M.-J.; Park S.-K.; Kim D.C.
- Ewha Authors
- 현동훈
- SCOPUS Author ID
- 현동훈
- Issue Date
- 2011
- Journal Title
- Plant Foods for Human Nutrition
- ISSN
- 0921-9668
- Citation
- Plant Foods for Human Nutrition vol. 66, no. 2, pp. 101 - 106
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- This study was performed to elucidate the anticancer mechanism of a lipid-soluble ginseng extract (LSGE) by analyzing induction of apoptosis and arrest of cell cycle progression using the NCI-H460 human lung cancer cell line. Proliferation of NCI-H460 cells was potently inhibited by LSGE in a dose-dependent manner. The cell cycle arrest at the G0/G1 phase in NCI-H460 cells was induced by LSGE. The percentage of G0/G1 phase cells significantly increased, while that of S phase cells decreased after treatment with LSGE. The expr.occurred through apoptosis, which was accompanied by increasing the activity of caspases including caspase-8, caspase-9 and caspase-3. Consistent with enhancement of caspase activity, LSGE increased protein levels of cleaved caspase-3, caspase-8, caspase-9, and poly-ADP-ribose polymerase (PARP). These apoptotic effects of LSGE were inhibited by the pan-caspase inhibitor Z-VAD-fmk. These findings indicate that LSGE inhibits NCI-H460 human lung cancer cell growth by cell cycle arrest at the G0/G1 phase and induction of caspase-mediated apoptosis. © 2011 Springer Science+Business Media, LLC.
- DOI
- 10.1007/s11130-011-0232-6
- Appears in Collections:
- 자연과학대학 > 생명과학전공 > Journal papers
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