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Hepatitis C virus infection is blocked by HMGB1 released from virus-infected cells

Title
Hepatitis C virus infection is blocked by HMGB1 released from virus-infected cells
Authors
Jung J.H.Park J.H.Jee M.H.Keum S.J.Cho M.-S.Yoon S.K.Jang S.K.
Ewha Authors
조민선
SCOPUS Author ID
조민선scopus
Issue Date
2011
Journal Title
Journal of Virology
ISSN
0022-538XJCR Link
Citation
vol. 85, no. 18, pp. 9359 - 9368
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
High-mobility group box 1 (HMGB1), an abundant nuclear protein that triggers host immune responses, is an endogenous danger signal involved in the pathogenesis of various infectious agents. However, its role in hepatitis C virus (HCV) infection is not known. Here, we show that HMGB1 protein is translocated from the nucleus to cytoplasm and subsequently is released into the extracellular milieu by HCV infection. Secreted HMGB1 triggers antiviral responses and blocks HCV infection, a mechanism that may limit HCV propagation in HCV patients. Secreted HMGB1 also may have a role in liver cirrhosis, which is a common comorbidity in HCV patients. Further investigations into the roles of HMGB1 in the diseases caused by HCV infection will shed light on and potentially help prevent these serious and prevalent HCV-related diseases. © 2011, American Society for Microbiology.
DOI
10.1128/JVI.00682-11
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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