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Neuropsychological correlates of the proportional impact of white matter hyperintensities on mild to moderate dementia: The MRI 300 study

Title
Neuropsychological correlates of the proportional impact of white matter hyperintensities on mild to moderate dementia: The MRI 300 study
Authors
Ku B.D.Na D.L.Moon S.Y.Kim S.Y.Seo S.W.Cheong H.-K.Park K.W.Park K.H.Lee J.-Y.Cha K.R.Shim Y.S.Youn Y.C.Chung C.-S.Kim J.E.Kang H.Y.Choi S.H.Han S.-H.
Ewha Authors
김지은
SCOPUS Author ID
김지은scopus
Issue Date
2011
Journal Title
Dementia and Geriatric Cognitive Disorders
ISSN
1420-8008JCR Link
Citation
vol. 31, no. 6, pp. 397 - 405
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Background: White matter hyperintensities (WMH) increase cognitive impairment in patients with dementia. Objective: We investigated the impact of WMH on the neuropsychological profiles in patients with mild to moderate dementia. Methods: We consecutively recruited newly diagnosed patients with mild to moderate dementia across South Korea for 1 year. The participants completed neuropsychological tests, magnetic resonance imaging, and structured neurological evaluations. The patients were divided into 3 categories, i.e. minimal, moderate, and severe WMH groups, according to the proportional degree of WMH. Results: 289 patients were recruited; 140 (48.3%) for the minimal WMH group, 99 (34.2%) for the moderate group, and 50 (17.5%) for the severe group. Both advanced age and low general cognitive level were significant contributors to WMH in patients with dementia. After adjusting for age, the neuropsychological correlates of the proportional impact of WMH were frontal executive, language, and attention profiles. However, the only significant neuropsychological correlate was the recognition memory profile after adjusting for both age and general cognitive level simultaneously. Conclusion: The results suggest that the most significant neuropsychological profile impacting the burden of WMH in patients with mild to moderate dementia was the recognition memory profile, regardless of age and general cognitive function. Copyright © 2011 S. Karger AG, Basel.
DOI
10.1159/000328624
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일반대학원 > 뇌·인지과학과 > Journal papers
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