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Conserved aquaporin 4 levels associated with reduction of brain edema are mediated by estrogen in the ischemic brain after experimental stroke

Title
Conserved aquaporin 4 levels associated with reduction of brain edema are mediated by estrogen in the ischemic brain after experimental stroke
Authors
Shin J.A.Choi J.H.Choi Y.-H.Park E.-M.
Ewha Authors
박은미최윤희최지하
SCOPUS Author ID
박은미scopus; 최윤희scopus; 최지하scopus
Issue Date
2011
Journal Title
Biochimica et Biophysica Acta - Molecular Basis of Disease
ISSN
0925-4439JCR Link
Citation
vol. 1812, no. 9, pp. 1154 - 1163
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Aquaporin 4 (AQP4), the most abundant water channel protein in the brain, is involved in brain edema induced by ischemic insults. To evaluate whether the neuroprotective effects of estrogen are associated with AQP4 expression and edema formation, changes in AQP levels and ischemic edema were examined in the brains of male and female mice subjected to transient middle cerebral artery occlusion. Infarct volume and edema formation were markedly less in females than in males. AQP4 expression in the ischemic cortex of females was relatively well preserved, whereas it was significantly decreased in males. These effects disappeared in ovariectomized females but were reversed by estrogen replacement. Furthermore, AQP4 expression was decreased with increased brain edema in females treated with ICI182,780, an estrogen receptor antagonist. These findings suggest that the estrogen effect on the reduction of ischemic brain edema is associated with the preserved level of AQP4 that is partly mediated by estrogen receptors. © 2011 Elsevier B.V.
DOI
10.1016/j.bbadis.2011.05.004
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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