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Acute respiratory distress syndrome caused by miliary tuberculosis: A multicentre survey in South Korea

Title
Acute respiratory distress syndrome caused by miliary tuberculosis: A multicentre survey in South Korea
Authors
Lee K.Kim J.H.Lee J.H.Lee W.-Y.Park M.S.Kim J.Y.Kim K.C.Lee M.-G.Jung K.-S.Kim Y.S.Shin Y.M.Koh Y.
Ewha Authors
이진화
SCOPUS Author ID
이진화scopus
Issue Date
2011
Journal Title
International Journal of Tuberculosis and Lung Disease
ISSN
1027-3719JCR Link
Citation
vol. 15, no. 8, pp. 1099 - 1103
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
BACKGROUND: Miliary tuberculosis (TB) is an unusual cause of acute respiratory distress syndrome (ARDS). OBJECTIVE: To evaluate the clinical characteristics and outcomes of patients with ARDS caused by miliary TB admitted to the intensive care unit (ICU). DESIGN: A total of 67 patients were enrolled during the period 1999-2008. RESULTS: The median age of the patients was 56 years (range 17-81), 19 (28.4%) were aged >71 years, and 38 (56.7%) were male. All-cause mortality in the ICU and hospital were respectively 58.2% and 61.2%. Of the total number of enrolled patients, 49 (73.1%) were prescribed anti-tuberculosis medication within 3 days of hospital admission. On the day of ARDS diagnosis (10.0 ± 3.7 vs. 7.4 ± 3.5, P = 0.005), non-survivors had a significantly higher Sequential Organ Failure Assessment (SOFA) score than survivors. Multivariate analysis showed that SOFA score on the day of ARDS diagnosis was a significant predictor of survival (OR 0.809, 95%CI 0.691-0.946, P = 0.008). It was difficult to determine the efficacy of systemic corticosteroids on patient survival. CONCLUSION: ARDS caused by miliary TB was associated with a high in-hospital mortality rate, with SOFA score on the day of ARDS diagnosis being a valuable prognostic indicator. © 2011 The Union.
DOI
10.5588/ijtld.10.0557
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의학전문대학원 > 의학과 > Journal papers
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