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Synthesis, cytotoxicity and topoisomerase II inhibitory activity of benzonaphthofurandiones

Title
Synthesis, cytotoxicity and topoisomerase II inhibitory activity of benzonaphthofurandiones
Authors
Rhee H.-K.Kwon Y.Chung H.-J.Lee S.K.Choo H.-Y.P.
Ewha Authors
박혜영권영주
SCOPUS Author ID
박혜영scopus; 권영주scopus
Issue Date
2011
Journal Title
Bulletin of the Korean Chemical Society
ISSN
0253-2964JCR Link
Citation
vol. 32, no. 7, pp. 2391 - 2396
Indexed
SCI; SCIE; SCOPUS; KCI WOS scopus
Abstract
Benzonaphthofurandiones containing four coplanar fused aromatic rings were synthesized and evaluated for their cytotoxicity against five human cancer cell lines, and their inhibitory activity on topoisomerases. These benzonaphthofurandiones were prepared by condensation of 2,3- dichloronaphthoquinone and three aromatic diols with base catalysts in alcohol. The synthesized compounds were o-alkylated with six dialkylaminoalkyl halides. The hydroxy derivatives (8a-8g) exhibited relatively potent cytotoxicity among the prepared compounds. These compounds were evaluated as excellent inhibitors against topoisomerase II (topo II). Especially, the hydroxy analogue with branched methyl side chain (8e) showed high cytotoxicity against cancer cell lines and good inhibitory activity on topo II.
DOI
10.5012/bkcs.2011.32.7.2391
Appears in Collections:
약학대학 > 약학과 > Journal papers
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