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Expression of tnf-α and il-1β in splenic dendritic cells and their serum levels in mouse sparganosis

Title
Expression of tnf-α and il-1β in splenic dendritic cells and their serum levels in mouse sparganosis
Authors
Yang H.-J.
Ewha Authors
양현종
SCOPUS Author ID
양현종scopus
Issue Date
2011
Journal Title
Korean Journal of Parasitology
ISSN
0023-4001JCR Link
Citation
vol. 49, no. 2, pp. 191 - 194
Indexed
SCIE; SCOPUS; KCI WOS scopus
Abstract
Sparganosis is a tissue invading helminthiasis infecting intermediate hosts, including humans. Strong immune responses are expected to occur in early phases of infection. Thus, we investigated cytokine expressions in splenic dendritic cells and in sera after experimental infection of mice. In splenic dendritic cells, TNF-α and IL-1β expression peaked at week 1 and week 3 post-infection (PI), respectively, and also early phase (week 2 PI) depressed cytokine expression was noticed. Serum IL-1β concentration increased significantly at week 2 PI and peaked at week 6 PI, and that of TNF-α peaked at week 6 PI. These results showed that pro-inflammatory cytokines, TNF-α and IL-1β, are chronologically regulated in mouse sparganosis. © 2011, Korean Society for Parasitology.
DOI
10.3347/kjp.2011.49.2.191
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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