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WHO classification of malignant lymphomas in Korea: Report of the third nationwide study
- WHO classification of malignant lymphomas in Korea: Report of the third nationwide study
- Kim J.-M.; Ko Y.-H.; Lee S.-S.; Huh J.; Kang C.S.; Kim C.W.; Kang Y.K.; Go J.H.; Kim M.K.; Kim W.-S.; Kim Y.J.; Kim H.-J.; Kim H.K.; Nam J.H.; Moon H.B.; Park C.-K.; Park T.I.; Oh Y.-H.; Lee D.W.; Lee J.S.; Lee J.; Lee H.; Lim S.-C.; Jang K.Y.; Chang H.-K.; Jeon Y.K.; Jung H.R.; Cho M.-S.; Cha H.J.; Choi S.J.; Han J.H.; Hong S.H.; Kim I.
- Ewha Authors
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- Korean Journal of Pathology
- Korean Journal of Pathology vol. 45, no. 3, pp. 254 - 260
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- Background: The aim of study was to determine the relative frequency of malignant lymphoma according to World Health Organization (WHO) classification in Korea. Methods: A total of 3,998 cases diagnosed at 31 institutes between 2005 and 2006 were enrolled. Information including age, gender, pathologic diagnosis, site of involvement and immunophenotypes were obtained. Results: The relative frequency of non-Hodgkin lymphoma (NHL) and Hodgkin lymphoma (HL) was 95.4% and 4.6%, respectively. B-cell lymphomas accounted for 77.6% of all NHL, while T/natural killer (T/NK)-cell lymphomas accounted for 22.4%. The most frequent subtypes of NHL were diffuse large B-cell lymphoma (42.7%), extranodal marginal zone B-cell lymphoma (MZBCL) of mucosa-associated lymphoid tissue (19.0%), NK/T-cell lymphoma (6.3%) and peripheral T-cell lymphoma (PTCL), unspecified (6.3%), in decreasing order. The relative frequency of HL was nodular sclerosis (47.4%), mixed cellularity (30.6%), and nodular lymphocyte predominant (12.1%) subtypes. Compared with a previous study in 1998, increase in gastric MZBCL and nodular sclerosis HL, and slight decrease of follicular lymphoma, PTCL, and NK/T-cell lymphoma were observed. Conclusions: Korea had lower rates of HL and follicular lymphoma, and higher rates of extranodal NHL, extranodal MZBCL, and NK/T-cell lymphoma of nasal type compared with Western countries. Changes in the relative frequency of lymphoma subtypes are likely ascribed to refined diagnostic criteria and a change in national health care policy.
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