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Synthesis of 2,4-diaryl chromenopyridines and evaluation of their topoisomerase i and II inhibitory activity, cytotoxicity, and structure-activity relationship

Title
Synthesis of 2,4-diaryl chromenopyridines and evaluation of their topoisomerase i and II inhibitory activity, cytotoxicity, and structure-activity relationship
Authors
Thapa U.Thapa P.Karki R.Yun M.Choi J.H.Jahng Y.Lee E.Jeon K.-H.Na Y.Ha E.-M.Cho W.-J.Kwon Y.Lee E.-S.
Ewha Authors
권영주
SCOPUS Author ID
권영주scopus
Issue Date
2011
Journal Title
European Journal of Medicinal Chemistry
ISSN
0223-5234JCR Link
Citation
vol. 46, no. 8, pp. 3201 - 3209
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Designed and synthesized were a series of 5H-chromeno[4,3-b]pyridines with substitution at 2- and 4-positions with various 5- or 6-membered heteroaromatics as antitumor agents. They were evaluated for topoisomerase I and II inhibitory activities as well as cytotoxicities against several human cancer cell lines. Structure-activity relationship study showed that 2-furyl or 2-thienyl at 2- or 4-position of central pyridine is crucial in displaying topo I or II inhibitory activity and cytotoxicity. © 2011 Elsevier Masson SAS. All rights reserved.
DOI
10.1016/j.ejmech.2011.04.029
Appears in Collections:
약학대학 > 약학과 > Journal papers
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