Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 권영주 | * |
dc.date.accessioned | 2016-08-28T12:08:55Z | - |
dc.date.available | 2016-08-28T12:08:55Z | - |
dc.date.issued | 2011 | * |
dc.identifier.issn | 0968-0896 | * |
dc.identifier.other | OAK-7742 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/221755 | - |
dc.description.abstract | 4-Amino-2-phenylquinazolines 7 were designed as bioisosteres of 3-arylisoquinolinamines 6 that were energy minimized to provide stable conformers. Interestingly, the 2-phenyl ring of 4-amino-2-phenylquinazolines was parallel to the quinazoline ring and improved their DNA intercalation ability in the DNA-topo I complex. Among the synthesized 4-amino group-substituted analogs, 4-cyclohexylamino-2-phenylquinazoline 7h exhibited potent topo I inhibitory activity and strong cytotoxicity. Interestingly, consistency was observed between the cytotoxicities and topo I activities in these quinazoline analogs, suggesting that the target of 4-amino-2-phenylquinazolines is limited to topo I. Molecular docking studies were performed with the Surflex-Dock program to afford the ideal interaction mode of the compound into the binding site of the DNA-topo I complex in order to clarify the topo I activity of 7h. © 2011 Elsevier Ltd. All rights reserved. | * |
dc.language | English | * |
dc.title | Design and synthesis of 4-amino-2-phenylquinazolines as novel topoisomerase i inhibitors with molecular modeling | * |
dc.type | Article | * |
dc.relation.issue | 14 | * |
dc.relation.volume | 19 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 4399 | * |
dc.relation.lastpage | 4404 | * |
dc.relation.journaltitle | Bioorganic and Medicinal Chemistry | * |
dc.identifier.doi | 10.1016/j.bmc.2011.05.012 | * |
dc.identifier.wosid | WOS:000292301200025 | * |
dc.identifier.scopusid | 2-s2.0-79959970934 | * |
dc.author.google | Le T.N. | * |
dc.author.google | Yang S.H. | * |
dc.author.google | Khadka D.B. | * |
dc.author.google | Van H.T.M. | * |
dc.author.google | Cho S.H. | * |
dc.author.google | Kwon Y. | * |
dc.author.google | Lee E.-S. | * |
dc.author.google | Lee K.-T. | * |
dc.author.google | Cho W.-J. | * |
dc.contributor.scopusid | 권영주(12446435600) | * |
dc.date.modifydate | 20240422124907 | * |